TY - JOUR
T1 - CRP and adiponectin and its oligomers in the metabolic syndrome
T2 - Evaluation of new laboratory-based biomarkers
AU - Devaraj, Sridevi
AU - Swarbrick, Michael M.
AU - Singh, Uma
AU - Adams-Huet, Beverley
AU - Havel, Peter J.
AU - Jialal, Ishwarla
PY - 2008/5
Y1 - 2008/5
N2 - The metabolic syndrome (MetS) confers an increased risk for diabetes and cardiovascular disease. Although high-sensitive C-reactive protein (hsCRP) concentrations are higher and adiponectin concentrations lower in MetS, there is no reliable biochemical measure that can capture its various features. We evaluated whether hsCRP, adiponectin, or the ratio of adiponectin or its oligomers, especially the high-molecular-weight (HMW) oligomer, to hsCRP predict MetS in 123 subjects with MetS compared with that in 91 healthy control subjects. MetS subjects had significantly higher hsCRP levels and lower total adiponectin and oligomer levels relative to control subjects (P < .0001). The HMW/total adiponectin and adiponectin/CRP ratios were significantly lower in MetS subjects than control subjects (P < .005). The odds ratio (OR) of MetS using the 75th percentile cutoff for CRP was 3.8 (95% confidence interval [CI], 2.1-6.8) and equivalent to low total adiponectin (OR, 2.5; 95% CI, 1.3-4.5), its oligomers, or the adiponectin/ hsCRP ratio (OR, 2.6; 95% CI, 1.5, 4.8). Thus, measurements of CRP, adiponectin, or its oligomers provide robust biomarkers for predicting MetS.
AB - The metabolic syndrome (MetS) confers an increased risk for diabetes and cardiovascular disease. Although high-sensitive C-reactive protein (hsCRP) concentrations are higher and adiponectin concentrations lower in MetS, there is no reliable biochemical measure that can capture its various features. We evaluated whether hsCRP, adiponectin, or the ratio of adiponectin or its oligomers, especially the high-molecular-weight (HMW) oligomer, to hsCRP predict MetS in 123 subjects with MetS compared with that in 91 healthy control subjects. MetS subjects had significantly higher hsCRP levels and lower total adiponectin and oligomer levels relative to control subjects (P < .0001). The HMW/total adiponectin and adiponectin/CRP ratios were significantly lower in MetS subjects than control subjects (P < .005). The odds ratio (OR) of MetS using the 75th percentile cutoff for CRP was 3.8 (95% confidence interval [CI], 2.1-6.8) and equivalent to low total adiponectin (OR, 2.5; 95% CI, 1.3-4.5), its oligomers, or the adiponectin/ hsCRP ratio (OR, 2.6; 95% CI, 1.5, 4.8). Thus, measurements of CRP, adiponectin, or its oligomers provide robust biomarkers for predicting MetS.
KW - Adiponectin
KW - Biomarker
KW - C-reactive protein
KW - Metabolic syndrome
UR - http://www.scopus.com/inward/record.url?scp=44849110323&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44849110323&partnerID=8YFLogxK
U2 - 10.1309/RN84K51B2JJY1Y0B
DO - 10.1309/RN84K51B2JJY1Y0B
M3 - Article
C2 - 18426744
AN - SCOPUS:44849110323
SN - 0002-9173
VL - 129
SP - 815
EP - 822
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 5
ER -