Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children

Adrienne G. Randolph, Peter W. Forbes, Rainer G. Gedeit, John H. Arnold, Randall C. Wetzel, Peter M. Luckett, Mary E. O'Neil, Shekhar T. Venkataraman, Kathleen L. Meert, Ira M. Cheifetz, Peter N. Cox, James H. Hanson

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Objective: The effect of fluid balance on respiratory outcomes for critically ill children has not been evaluated. The only indicator of fluid balance routinely recorded across our intensive care units was estimated fluid intake and output. We sought to determine whether cumulative intake minus output (I-O) at the start of weaning predicted weaning duration and whether cumulative I-O at extubation predicted extubation failure. Design: Prospective observational study. Setting: Ten pediatric intensive care units. Patients: Cumulative I-O was recorded daily for 301 mechanically ventilated children (<18 yrs of age) from November 1999 through April 2001. Interventions: Cumulative I-O was recorded during a study of weaning strategies and extubation failure in which mechanical ventilation of the majority of patients during weaning and extubation was managed according to a protocol that did not include fluid balance indicators. Outcomes were the time to successful removal of ventilatory support and the rate of initial extubation failure. Measurements and Main Results: Relationships between cumulative I-O and outcomes were assessed by means of proportional hazards and logistic regression. The mean cumulative I-O per kilogram of ideal body weight at the start of weaning was 101 mL (SD, 180). Cumulative I-O at the time weaning was initiated did not predict duration of mechanical ventilator weaning. The mean cumulative I-O per kilogram of ideal body weight at extubation was 136 mL (SD, 237). Cumulative I-O at extubation did not predict extubation outcome. There was an association between cumulative I-O at extubation and the duration of weaning in cases not managed by a protocol. Conclusion: Although routinely recorded, cumulative fluid I-O does not appear to have clinical utility in cases managed according to a mechanical ventilator protocol in which tidal volume and oxygenation on minimal levels of ventilator support are systematically tested.

Original languageEnglish (US)
JournalPediatric Critical Care Medicine
Volume6
Issue number6
DOIs
StatePublished - Nov 2005

Fingerprint

Ventilator Weaning
Weaning
Water-Electrolyte Balance
Ideal Body Weight
Mechanical Ventilators
Pediatric Intensive Care Units
Tidal Volume
Artificial Respiration
Critical Illness
Observational Studies
Intensive Care Units
Logistic Models
Prospective Studies

Keywords

  • Extubation
  • Fluid balance
  • Mechanical ventilation
  • Pediatric

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Critical Care and Intensive Care Medicine

Cite this

Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children. / Randolph, Adrienne G.; Forbes, Peter W.; Gedeit, Rainer G.; Arnold, John H.; Wetzel, Randall C.; Luckett, Peter M.; O'Neil, Mary E.; Venkataraman, Shekhar T.; Meert, Kathleen L.; Cheifetz, Ira M.; Cox, Peter N.; Hanson, James H.

In: Pediatric Critical Care Medicine, Vol. 6, No. 6, 11.2005.

Research output: Contribution to journalArticle

Randolph, AG, Forbes, PW, Gedeit, RG, Arnold, JH, Wetzel, RC, Luckett, PM, O'Neil, ME, Venkataraman, ST, Meert, KL, Cheifetz, IM, Cox, PN & Hanson, JH 2005, 'Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children', Pediatric Critical Care Medicine, vol. 6, no. 6. https://doi.org/10.1097/01.PCC.0000185484.14423.0D
Randolph, Adrienne G. ; Forbes, Peter W. ; Gedeit, Rainer G. ; Arnold, John H. ; Wetzel, Randall C. ; Luckett, Peter M. ; O'Neil, Mary E. ; Venkataraman, Shekhar T. ; Meert, Kathleen L. ; Cheifetz, Ira M. ; Cox, Peter N. ; Hanson, James H. / Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children. In: Pediatric Critical Care Medicine. 2005 ; Vol. 6, No. 6.
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abstract = "Objective: The effect of fluid balance on respiratory outcomes for critically ill children has not been evaluated. The only indicator of fluid balance routinely recorded across our intensive care units was estimated fluid intake and output. We sought to determine whether cumulative intake minus output (I-O) at the start of weaning predicted weaning duration and whether cumulative I-O at extubation predicted extubation failure. Design: Prospective observational study. Setting: Ten pediatric intensive care units. Patients: Cumulative I-O was recorded daily for 301 mechanically ventilated children (<18 yrs of age) from November 1999 through April 2001. Interventions: Cumulative I-O was recorded during a study of weaning strategies and extubation failure in which mechanical ventilation of the majority of patients during weaning and extubation was managed according to a protocol that did not include fluid balance indicators. Outcomes were the time to successful removal of ventilatory support and the rate of initial extubation failure. Measurements and Main Results: Relationships between cumulative I-O and outcomes were assessed by means of proportional hazards and logistic regression. The mean cumulative I-O per kilogram of ideal body weight at the start of weaning was 101 mL (SD, 180). Cumulative I-O at the time weaning was initiated did not predict duration of mechanical ventilator weaning. The mean cumulative I-O per kilogram of ideal body weight at extubation was 136 mL (SD, 237). Cumulative I-O at extubation did not predict extubation outcome. There was an association between cumulative I-O at extubation and the duration of weaning in cases not managed by a protocol. Conclusion: Although routinely recorded, cumulative fluid I-O does not appear to have clinical utility in cases managed according to a mechanical ventilator protocol in which tidal volume and oxygenation on minimal levels of ventilator support are systematically tested.",
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T1 - Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children

AU - Randolph, Adrienne G.

AU - Forbes, Peter W.

AU - Gedeit, Rainer G.

AU - Arnold, John H.

AU - Wetzel, Randall C.

AU - Luckett, Peter M.

AU - O'Neil, Mary E.

AU - Venkataraman, Shekhar T.

AU - Meert, Kathleen L.

AU - Cheifetz, Ira M.

AU - Cox, Peter N.

AU - Hanson, James H.

PY - 2005/11

Y1 - 2005/11

N2 - Objective: The effect of fluid balance on respiratory outcomes for critically ill children has not been evaluated. The only indicator of fluid balance routinely recorded across our intensive care units was estimated fluid intake and output. We sought to determine whether cumulative intake minus output (I-O) at the start of weaning predicted weaning duration and whether cumulative I-O at extubation predicted extubation failure. Design: Prospective observational study. Setting: Ten pediatric intensive care units. Patients: Cumulative I-O was recorded daily for 301 mechanically ventilated children (<18 yrs of age) from November 1999 through April 2001. Interventions: Cumulative I-O was recorded during a study of weaning strategies and extubation failure in which mechanical ventilation of the majority of patients during weaning and extubation was managed according to a protocol that did not include fluid balance indicators. Outcomes were the time to successful removal of ventilatory support and the rate of initial extubation failure. Measurements and Main Results: Relationships between cumulative I-O and outcomes were assessed by means of proportional hazards and logistic regression. The mean cumulative I-O per kilogram of ideal body weight at the start of weaning was 101 mL (SD, 180). Cumulative I-O at the time weaning was initiated did not predict duration of mechanical ventilator weaning. The mean cumulative I-O per kilogram of ideal body weight at extubation was 136 mL (SD, 237). Cumulative I-O at extubation did not predict extubation outcome. There was an association between cumulative I-O at extubation and the duration of weaning in cases not managed by a protocol. Conclusion: Although routinely recorded, cumulative fluid I-O does not appear to have clinical utility in cases managed according to a mechanical ventilator protocol in which tidal volume and oxygenation on minimal levels of ventilator support are systematically tested.

AB - Objective: The effect of fluid balance on respiratory outcomes for critically ill children has not been evaluated. The only indicator of fluid balance routinely recorded across our intensive care units was estimated fluid intake and output. We sought to determine whether cumulative intake minus output (I-O) at the start of weaning predicted weaning duration and whether cumulative I-O at extubation predicted extubation failure. Design: Prospective observational study. Setting: Ten pediatric intensive care units. Patients: Cumulative I-O was recorded daily for 301 mechanically ventilated children (<18 yrs of age) from November 1999 through April 2001. Interventions: Cumulative I-O was recorded during a study of weaning strategies and extubation failure in which mechanical ventilation of the majority of patients during weaning and extubation was managed according to a protocol that did not include fluid balance indicators. Outcomes were the time to successful removal of ventilatory support and the rate of initial extubation failure. Measurements and Main Results: Relationships between cumulative I-O and outcomes were assessed by means of proportional hazards and logistic regression. The mean cumulative I-O per kilogram of ideal body weight at the start of weaning was 101 mL (SD, 180). Cumulative I-O at the time weaning was initiated did not predict duration of mechanical ventilator weaning. The mean cumulative I-O per kilogram of ideal body weight at extubation was 136 mL (SD, 237). Cumulative I-O at extubation did not predict extubation outcome. There was an association between cumulative I-O at extubation and the duration of weaning in cases not managed by a protocol. Conclusion: Although routinely recorded, cumulative fluid I-O does not appear to have clinical utility in cases managed according to a mechanical ventilator protocol in which tidal volume and oxygenation on minimal levels of ventilator support are systematically tested.

KW - Extubation

KW - Fluid balance

KW - Mechanical ventilation

KW - Pediatric

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