We have a better understanding of the pathogenesis of skin diseases in patients with HIV infection. It is apparent that the effects of HIV on the immune system are much more complex than simple depletion of CD4 lymphocytes. Subsets of T-helper cells, referred to as Th1 and Th2, have been found to play significant roles in HIV infection and AIDS. Th1 cells predominate in the normal state in immunocompetent individuals. Th1 lymphocytes promote cellular immunity and produce interleukin (IL)-2, IL-12, and interferon gamma to eradicate infection. Th2 lymphocytes promote humoral immunity and produce IL-4, IL-5, IL-10, and allergic responses. Th1 cells suppress Th2 cells, and vice versa.
|Original language||English (US)|
|Title of host publication||Mucocutaneous Manifestations of Viral Diseases|
|Number of pages||90|
|State||Published - Jan 1 2002|
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