Cutaneous manifestations of HIV Infection

Clay J Cockerell; Philip R. Cohen

Cutaneous manifestations of HIV Infection

Clay J Cockerell, Philip R. Cohen

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

We have a better understanding of the pathogenesis of skin diseases in patients with HIV infection. It is apparent that the effects of HIV on the immune system are much more complex than simple depletion of CD4 lymphocytes. Subsets of T-helper cells, referred to as Th1 and Th2, have been found to play significant roles in HIV infection and AIDS. Th1 cells predominate in the normal state in immunocompetent individuals. Th1 lymphocytes promote cellular immunity and produce interleukin (IL)-2, IL-12, and interferon gamma to eradicate infection. Th2 lymphocytes promote humoral immunity and produce IL-4, IL-5, IL-10, and allergic responses. Th1 cells suppress Th2 cells, and vice versa.

Original language	English (US)
Title of host publication	Mucocutaneous Manifestations of Viral Diseases
Publisher	CRC Press
Pages	307-396
Number of pages	90
ISBN (Electronic)	9780203910733
ISBN (Print)	9780824704506
State	Published - Jan 1 2002

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Cutaneous manifestations of HIV Infection",

abstract = "We have a better understanding of the pathogenesis of skin diseases in patients with HIV infection. It is apparent that the effects of HIV on the immune system are much more complex than simple depletion of CD4 lymphocytes. Subsets of T-helper cells, referred to as Th1 and Th2, have been found to play significant roles in HIV infection and AIDS. Th1 cells predominate in the normal state in immunocompetent individuals. Th1 lymphocytes promote cellular immunity and produce interleukin (IL)-2, IL-12, and interferon gamma to eradicate infection. Th2 lymphocytes promote humoral immunity and produce IL-4, IL-5, IL-10, and allergic responses. Th1 cells suppress Th2 cells, and vice versa.",

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AB - We have a better understanding of the pathogenesis of skin diseases in patients with HIV infection. It is apparent that the effects of HIV on the immune system are much more complex than simple depletion of CD4 lymphocytes. Subsets of T-helper cells, referred to as Th1 and Th2, have been found to play significant roles in HIV infection and AIDS. Th1 cells predominate in the normal state in immunocompetent individuals. Th1 lymphocytes promote cellular immunity and produce interleukin (IL)-2, IL-12, and interferon gamma to eradicate infection. Th2 lymphocytes promote humoral immunity and produce IL-4, IL-5, IL-10, and allergic responses. Th1 cells suppress Th2 cells, and vice versa.

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M3 - Chapter

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EP - 396

BT - Mucocutaneous Manifestations of Viral Diseases

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ER -

Cutaneous manifestations of HIV Infection

Abstract

ASJC Scopus subject areas

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