Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-κB pathway

Lauren S. Collier-Hyams, Hui Zeng, Jun Sun, Amelia D. Tomlinson, Zhao Qin Bao, Huaqun Chen, James L. Madara, Kim Orth, Andrew S. Neish

Research output: Contribution to journalArticle

210 Scopus citations

Abstract

Secreted prokaryotic effector proteins have evolved to modulate the cellular functions of specific eukaryotic hosts. Generally, these proteins are considered virulence factors that facilitate parasitism. However, in certain plant and insect eukaryotic/prokaryotic relationships, effector proteins are involved in the establishment of commensal or symbiotic interactions. In this study, we report that the AvrA protein from Salmonella typhimurium, a common enteropathogen of humans, is an effector molecule that inhibits activation of the key proinflammatory NF-κB transcription factor and augments apoptosis in human epithelial cells. This activity is similar but mechanistically distinct from that described for YopJ, an AvrA homolog expressed by the bacterial pathogen Yersinia. We suggest that AvrA may limit virulence in vertebrates in a manner analogous to avirulence factors in plants, and as such, is the first bacterial effector from a mammalian pathogen that has been ascribed such a function.

Original languageEnglish (US)
Pages (from-to)2846-2850
Number of pages5
JournalJournal of Immunology
Volume169
Issue number6
StatePublished - Sep 15 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Collier-Hyams, L. S., Zeng, H., Sun, J., Tomlinson, A. D., Bao, Z. Q., Chen, H., Madara, J. L., Orth, K., & Neish, A. S. (2002). Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-κB pathway. Journal of Immunology, 169(6), 2846-2850.