Cyclic adenosine 3':5'-Monophosphate-binding protein, a biochemical marker of neuroblastoma differentiation

N. Prashad, R. Rosenberg, F. Baskin, D. Sparkman, C. Ulrich, B. Wischmeyer

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Mouse neuroblastoma tumors show reduced amounts of cyclic adenosine 3':5'-monophosphate (cAMP) binding protein, the level of cAMP-binding protein was increased by 2-fold when the tumor cells were established in tissue culture, and these levels were comparable to that found in mouse brain. This binding protein is a free cAMP-binding protein that is not associated with protein kinase. The reduced amounts of free cAMP-binding protein in tumors are not a consequence of a defective gene, but the synthesis of this protein is regulated at the transcriptional and/or translational levels. The free cAMP-binding protein like the neurotransmitter-synthesizing enzymes can be used as a biochemical marker of differentiation, and this protein may play a role in neuronal differentiation.

Original languageEnglish (US)
Pages (from-to)I
JournalCancer Research
Volume40
Issue number8
StatePublished - Nov 10 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Cyclic adenosine 3':5'-Monophosphate-binding protein, a biochemical marker of neuroblastoma differentiation'. Together they form a unique fingerprint.

  • Cite this