Cystic renal neoplasia following conditional inactivation of Apc in mouse renal tubular epithelium

Chao Nan Qian, Jared Knol, Peter Igarashi, Fangming Lin, Uko Zylstra, Bin Tean Teh, Bart O. Williams

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

Alterations in Wnt/β-catenin signaling have been linked to abnormal kidney development and tumorigenesis. To gain more insights into the effects of these alterations, we created mice carrying a conditional deletion of the Apc tumor suppressor gene specifically in the renal epithelium. As expected, the loss of Apc leads to increased levels of β-catenin protein in renal epithelium. Most of these mice die shortly after birth, and multiple kidney cysts were found upon histological examination. Only rarely did these animals survive to adulthood. Analysis of these adults revealed severely cystic kidneys associated with the presence of renal adenomas. Our results confirm an important role for proper regulation of Wnt/β-catenin signaling in renal development and provide evidence that dysregulation of the pathway can initiate tumorigenesis in the kidney.

Original languageEnglish (US)
Pages (from-to)3938-3945
Number of pages8
JournalJournal of Biological Chemistry
Volume280
Issue number5
DOIs
StatePublished - Feb 4 2005

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Qian, C. N., Knol, J., Igarashi, P., Lin, F., Zylstra, U., Teh, B. T., & Williams, B. O. (2005). Cystic renal neoplasia following conditional inactivation of Apc in mouse renal tubular epithelium. Journal of Biological Chemistry, 280(5), 3938-3945. https://doi.org/10.1074/jbc.M410697200