Cystic sebaceous neoplasms in Muir-Torre syndrome

Jared J. Abbott, Pablo Hernandez-Rios, Robin H. Amirkhan, Mai P. Hoang

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Cystic sebaceous neoplasms have been seen only in patients with Muir-Torre syndrome (MTS) and have recently been characterized as marker lesions of MTS. Histologically, these lesions form a spectrum of tumors ranging from benign cystic adenomas to proliferative cystic sebaceous tumors. We describe 2 proliferative cystic sebaceous tumors in a 53-year-old man whose workup revealed colonic adenocarcinoma and other sebaceous tumors consistent with MTS. Both the chest wall and the left thigh masses were grossly cystic, measuring 1.0 and 1.5 cm, respectively. Histologic sections demonstrated well-circumscribed cystic neoplasms located in the deep dermis and subcutaneous tissue. Each had a focally infolded cyst wall composed of immature basaloid cells with prominent nucleoli and mitoses, consistent with a proliferative cystic sebaceous tumor. Recognition of cystic sebaceous neoplasm by pathologists and communication to clinicians of its strong association with MTS is of diagnostic importance.

Original languageEnglish (US)
Pages (from-to)614-617
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume127
Issue number5
StatePublished - May 1 2003

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Muir-Torre Syndrome
Neoplasms
Sebaceous Adenocarcinoma
Subcutaneous Tissue
Thoracic Wall
Dermis
Thigh
Mitosis
Adenoma
Cysts
Communication

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Abbott, J. J., Hernandez-Rios, P., Amirkhan, R. H., & Hoang, M. P. (2003). Cystic sebaceous neoplasms in Muir-Torre syndrome. Archives of Pathology and Laboratory Medicine, 127(5), 614-617.

Cystic sebaceous neoplasms in Muir-Torre syndrome. / Abbott, Jared J.; Hernandez-Rios, Pablo; Amirkhan, Robin H.; Hoang, Mai P.

In: Archives of Pathology and Laboratory Medicine, Vol. 127, No. 5, 01.05.2003, p. 614-617.

Research output: Contribution to journalArticle

Abbott, JJ, Hernandez-Rios, P, Amirkhan, RH & Hoang, MP 2003, 'Cystic sebaceous neoplasms in Muir-Torre syndrome', Archives of Pathology and Laboratory Medicine, vol. 127, no. 5, pp. 614-617.
Abbott, Jared J. ; Hernandez-Rios, Pablo ; Amirkhan, Robin H. ; Hoang, Mai P. / Cystic sebaceous neoplasms in Muir-Torre syndrome. In: Archives of Pathology and Laboratory Medicine. 2003 ; Vol. 127, No. 5. pp. 614-617.
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