Cytogenetic abnormalities in patients with cutaneous T-cell lymphomas

J. Whang-Peng, P. Bunn, T. Knutsen, G. P. Schechter, A. F. Gazdar, M. J. Matthews, J. D. Minna

Research output: Contribution to journalArticle

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Abstract

Cytogenetic studies were conducted in 36 patients with histologically confirmed cutaneous T-cell lymphomas at the National Cancer Institute-Veterans' Administration Medical Oncology Branch. Aneuploidy was observed in 17 (85%) of the 20 lymph nodes, 23 of the 36 peripheral bloods, and five of the 31 bone marrows. Aneuploidy was frequently present even when tumor cells were not noted histologically. These findings indicate that cytogenetic studies can be very useful for the early detection of malignant cells even when only a few such neoplastic cells are encountered. In this study, the cytogenetic abnormalities found to be characteristic of these diseases included extensive aneuploidy, with both numerical and structural aberrations, a wide range of heteroploidy, and a lack of clone formation until the terminal phase of the disease. The numerical changes most frequently involved chromosomes 8, 15, 11, 17, 21, and 10, and the chromosome most involved in structural aberrations was chromosome 1, followed by chromosome 7, 14, 16, 6, and 9. Cytogenetic studies demonstrate that neoplasia in the cutaneous T-cell lymphomas commonly involves areas beyond the skin.

Original languageEnglish (US)
Pages (from-to)575-580
Number of pages6
JournalCancer Treatment Reports
Volume63
Issue number4
StatePublished - 1979

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Cutaneous T-Cell Lymphoma
Aneuploidy
Cytogenetics
Chromosome Aberrations
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 10
United States Department of Veterans Affairs
Chromosomes, Human, Pair 7
Medical Oncology
National Cancer Institute (U.S.)
Chromosomes, Human, Pair 1
Neoplasms
Clone Cells
Lymph Nodes
Bone Marrow
Skin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Whang-Peng, J., Bunn, P., Knutsen, T., Schechter, G. P., Gazdar, A. F., Matthews, M. J., & Minna, J. D. (1979). Cytogenetic abnormalities in patients with cutaneous T-cell lymphomas. Cancer Treatment Reports, 63(4), 575-580.

Cytogenetic abnormalities in patients with cutaneous T-cell lymphomas. / Whang-Peng, J.; Bunn, P.; Knutsen, T.; Schechter, G. P.; Gazdar, A. F.; Matthews, M. J.; Minna, J. D.

In: Cancer Treatment Reports, Vol. 63, No. 4, 1979, p. 575-580.

Research output: Contribution to journalArticle

Whang-Peng, J, Bunn, P, Knutsen, T, Schechter, GP, Gazdar, AF, Matthews, MJ & Minna, JD 1979, 'Cytogenetic abnormalities in patients with cutaneous T-cell lymphomas', Cancer Treatment Reports, vol. 63, no. 4, pp. 575-580.
Whang-Peng J, Bunn P, Knutsen T, Schechter GP, Gazdar AF, Matthews MJ et al. Cytogenetic abnormalities in patients with cutaneous T-cell lymphomas. Cancer Treatment Reports. 1979;63(4):575-580.
Whang-Peng, J. ; Bunn, P. ; Knutsen, T. ; Schechter, G. P. ; Gazdar, A. F. ; Matthews, M. J. ; Minna, J. D. / Cytogenetic abnormalities in patients with cutaneous T-cell lymphomas. In: Cancer Treatment Reports. 1979 ; Vol. 63, No. 4. pp. 575-580.
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