Decay-accelerating factor functions as a signal transducing molecule for human T cells

L. S. Davis, S. S. Patel, J. P. Atkinson, P. E. Lipsky

Research output: Contribution to journalArticlepeer-review

141 Scopus citations

Abstract

Decay accelerating factor (DAF) is a cell surface protein that protects cells from autologous C-mediated lysis. DAF is one of the first phosphatidylinositol-linked molecules to be described on human T cells. The current studies demonstrate that low levels of DAF are expressed on a majority of freshly isolated human T cells and that DAF expression rapidly increases after T cell activation by mitogens. Moreover, antibodies to DAF induce T cell proliferation when the cells are co-stimulated with phorbol esters. The induction of proliferation is facilitated when the antibodies to DAF cross-linked with a secondary antibody. T cell mitogenesis is largely dependent on the phosphatidylinositol-linked form of DAF, because removal of DAF by a phosphatidylinositol-specific phospholipase C eliminates anti-DAF-induced T cell proliferation. These studies suggest that DAF on the surface of T cells may not only serve to afford protection from autologous C but may also function to transmit signals that induce T cell activation.

Original languageEnglish (US)
Pages (from-to)2246-2252
Number of pages7
JournalJournal of Immunology
Volume141
Issue number7
StatePublished - 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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