Deconstructing the relationship between genetics and race

Michael Bamshad, Stephen Wooding, Benjamin A. Salisbury, J. Claiborne Stephens

Research output: Contribution to journalArticle

224 Citations (Scopus)

Abstract

The success of many strategies for finding genetic variants that underlie complex traits depends on how genetic variation is distributed among human populations. This realization has intensified the investigation of genetic differences among groups, which are often defined by commonly used racial labels. Some scientists argue that race is an adequate proxy of ancestry, whereas others claim that race belies how genetic variation is apportioned. Resolving this controversy depends on understanding the complicated relationship between race, ancestry and the demographic history of humans. Recent discoveries are helping us to deconstruct this relationship, and provide better guidance to scientists and policy makers.

Original languageEnglish (US)
Pages (from-to)598-609
Number of pages12
JournalNature Reviews Genetics
Volume5
Issue number8
DOIs
StatePublished - Aug 2004

Fingerprint

ancestry
genetic variation
Proxy
Administrative Personnel
human population
demographic statistics
History
Demography
history
Population

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

Bamshad, M., Wooding, S., Salisbury, B. A., & Stephens, J. C. (2004). Deconstructing the relationship between genetics and race. Nature Reviews Genetics, 5(8), 598-609. https://doi.org/10.1038/nrg1401

Deconstructing the relationship between genetics and race. / Bamshad, Michael; Wooding, Stephen; Salisbury, Benjamin A.; Stephens, J. Claiborne.

In: Nature Reviews Genetics, Vol. 5, No. 8, 08.2004, p. 598-609.

Research output: Contribution to journalArticle

Bamshad, M, Wooding, S, Salisbury, BA & Stephens, JC 2004, 'Deconstructing the relationship between genetics and race', Nature Reviews Genetics, vol. 5, no. 8, pp. 598-609. https://doi.org/10.1038/nrg1401
Bamshad M, Wooding S, Salisbury BA, Stephens JC. Deconstructing the relationship between genetics and race. Nature Reviews Genetics. 2004 Aug;5(8):598-609. https://doi.org/10.1038/nrg1401
Bamshad, Michael ; Wooding, Stephen ; Salisbury, Benjamin A. ; Stephens, J. Claiborne. / Deconstructing the relationship between genetics and race. In: Nature Reviews Genetics. 2004 ; Vol. 5, No. 8. pp. 598-609.
@article{22fda5542b5948dabe3ff348e9415ed3,
title = "Deconstructing the relationship between genetics and race",
abstract = "The success of many strategies for finding genetic variants that underlie complex traits depends on how genetic variation is distributed among human populations. This realization has intensified the investigation of genetic differences among groups, which are often defined by commonly used racial labels. Some scientists argue that race is an adequate proxy of ancestry, whereas others claim that race belies how genetic variation is apportioned. Resolving this controversy depends on understanding the complicated relationship between race, ancestry and the demographic history of humans. Recent discoveries are helping us to deconstruct this relationship, and provide better guidance to scientists and policy makers.",
author = "Michael Bamshad and Stephen Wooding and Salisbury, {Benjamin A.} and Stephens, {J. Claiborne}",
year = "2004",
month = "8",
doi = "10.1038/nrg1401",
language = "English (US)",
volume = "5",
pages = "598--609",
journal = "Nature reviews. Genetics",
issn = "1471-0056",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - Deconstructing the relationship between genetics and race

AU - Bamshad, Michael

AU - Wooding, Stephen

AU - Salisbury, Benjamin A.

AU - Stephens, J. Claiborne

PY - 2004/8

Y1 - 2004/8

N2 - The success of many strategies for finding genetic variants that underlie complex traits depends on how genetic variation is distributed among human populations. This realization has intensified the investigation of genetic differences among groups, which are often defined by commonly used racial labels. Some scientists argue that race is an adequate proxy of ancestry, whereas others claim that race belies how genetic variation is apportioned. Resolving this controversy depends on understanding the complicated relationship between race, ancestry and the demographic history of humans. Recent discoveries are helping us to deconstruct this relationship, and provide better guidance to scientists and policy makers.

AB - The success of many strategies for finding genetic variants that underlie complex traits depends on how genetic variation is distributed among human populations. This realization has intensified the investigation of genetic differences among groups, which are often defined by commonly used racial labels. Some scientists argue that race is an adequate proxy of ancestry, whereas others claim that race belies how genetic variation is apportioned. Resolving this controversy depends on understanding the complicated relationship between race, ancestry and the demographic history of humans. Recent discoveries are helping us to deconstruct this relationship, and provide better guidance to scientists and policy makers.

UR - http://www.scopus.com/inward/record.url?scp=3442881708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3442881708&partnerID=8YFLogxK

U2 - 10.1038/nrg1401

DO - 10.1038/nrg1401

M3 - Article

C2 - 15266342

AN - SCOPUS:3442881708

VL - 5

SP - 598

EP - 609

JO - Nature reviews. Genetics

JF - Nature reviews. Genetics

SN - 1471-0056

IS - 8

ER -