Decreased androgen receptor expression is associated with distant metastases in patients with androgen receptor-expressing triple-negative breast carcinoma

Lisa M. Sutton, Dengfeng Cao, Venetia Sarode, Kyle H. Molberg, Kwame Torgbe, Barbara Haley, Yan Peng

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

To characterize prognostic values of androgen receptor (AR) in triple-negative (TN) breast cancers, we investigated AR expression status and levels, explored an association of AR expression with metastatic disease, and correlated AR expression with Ki-67 in TN invasive breast carcinomas. AR expression was analyzed with immunohistochemistry in 121 cases of TN tumors. Thirty-nine cases had distant metastatic disease and 82 had locoregional disease only. AR was positive in 38 (31.4%) of the 121 cases. Our results indicate that among the AR-positive TN tumors, distant metastases are significantly associated with lower expression of AR compared with cases with only locoregional disease, and that AR expression negatively correlates with Ki-67 expression. These findings suggest that decreased intratumoral AR expression may be predictive of distant metastatic disease and AR expression levels may have potential prognostic value in AR-expressing TN tumors.

Original languageEnglish (US)
Pages (from-to)511-516
Number of pages6
JournalAmerican journal of clinical pathology
Volume138
Issue number4
DOIs
StatePublished - Oct 1 2012

Keywords

  • Androgen receptor
  • Distant metastasis
  • Triple-negative breast cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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