TY - JOUR
T1 - Decreased caudate volume in neuroleptic-naive psychotic patients
AU - Keshavan, Matcheri S.
AU - Rosenberg, David
AU - Sweeney, John A.
AU - Pettegrew, Jay W.
PY - 1998
Y1 - 1998
N2 - Objective: Previous studies, mostly involving neuroleptic-treated patients, have suggested enlarged basal ganglia size in schizophrenia. The authors sought to examine basal ganglia volume in neuroleptic-naive psychotic patients. Method: Magnetic resonance imaging volumetric studies were conducted in newly diagnosed neuroleptic-naive schizophrenic and non- schizophrenic psychotic patients and in matched healthy comparison subjects. Results: Both patient groups had bilaterally reduced caudate, but not putamen, volumes, compared to the healthy subjects, after adjustment for intracranial volume. Conclusions: Decreases in caudate volume in newly diagnosed psychotic patients may be related to the primary pathophysiology of these disorders; prior observations of increased caudate volume may reflect effects of neuroleptic treatment.
AB - Objective: Previous studies, mostly involving neuroleptic-treated patients, have suggested enlarged basal ganglia size in schizophrenia. The authors sought to examine basal ganglia volume in neuroleptic-naive psychotic patients. Method: Magnetic resonance imaging volumetric studies were conducted in newly diagnosed neuroleptic-naive schizophrenic and non- schizophrenic psychotic patients and in matched healthy comparison subjects. Results: Both patient groups had bilaterally reduced caudate, but not putamen, volumes, compared to the healthy subjects, after adjustment for intracranial volume. Conclusions: Decreases in caudate volume in newly diagnosed psychotic patients may be related to the primary pathophysiology of these disorders; prior observations of increased caudate volume may reflect effects of neuroleptic treatment.
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M3 - Article
C2 - 9619149
AN - SCOPUS:0031747408
SN - 0002-953X
VL - 155
SP - 774
EP - 778
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 6
ER -