Decreased caudate volume in neuroleptic-naive psychotic patients

Matcheri S. Keshavan, David Rosenberg, John A. Sweeney, Jay W. Pettegrew

Research output: Contribution to journalArticle

175 Scopus citations

Abstract

Objective: Previous studies, mostly involving neuroleptic-treated patients, have suggested enlarged basal ganglia size in schizophrenia. The authors sought to examine basal ganglia volume in neuroleptic-naive psychotic patients. Method: Magnetic resonance imaging volumetric studies were conducted in newly diagnosed neuroleptic-naive schizophrenic and non- schizophrenic psychotic patients and in matched healthy comparison subjects. Results: Both patient groups had bilaterally reduced caudate, but not putamen, volumes, compared to the healthy subjects, after adjustment for intracranial volume. Conclusions: Decreases in caudate volume in newly diagnosed psychotic patients may be related to the primary pathophysiology of these disorders; prior observations of increased caudate volume may reflect effects of neuroleptic treatment.

Original languageEnglish (US)
Pages (from-to)774-778
Number of pages5
JournalAmerican Journal of Psychiatry
Volume155
Issue number6
StatePublished - Jun 13 1998

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Keshavan, M. S., Rosenberg, D., Sweeney, J. A., & Pettegrew, J. W. (1998). Decreased caudate volume in neuroleptic-naive psychotic patients. American Journal of Psychiatry, 155(6), 774-778.