Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio

Shunsuke Yamada, Masanori Tokumoto, Masatomo Taniguchi, Hidehisa Kitada, Kazuhiko Tsuruya, Takanari Kitazono

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 34-year-old female hemodialysis patient with an abnormal whole parathyroid hormone (PTH)/intact PTH ratio (ratio = 1.14) underwent parathyroidectomy for advanced secondary hyperparathyroidism. The abnormal PTH ratio indicated a relative increase in the serum N-terminus PTH, a new molecular form of PTH. The abnormal ratio normalized immediately after the largest parathyroid gland (PTG) was removed, proving the largest PTG as causative. An immunohistochemical analysis revealed extremely decreased expression of the calcium-sensing receptor and parafibromin in the largest PTG in comparison with the other PTGs. This case indicated the possible involvement of decreased calcium-sensing receptor and parafibromin signaling in the development of the abnormal PTH ratio.

Original languageEnglish (US)
Pages (from-to)429-432
Number of pages4
JournalClinical Kidney Journal
Volume6
Issue number4
DOIs
StatePublished - 2013

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Calcium-Sensing Receptors
Secondary Hyperparathyroidism
Parathyroid Hormone
Parathyroid Glands
Parathyroidectomy
Renal Dialysis
Serum

Keywords

  • calcium-sensing receptor
  • N-terminus PTH
  • parafibromin
  • secondary hyperparathyroidism

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio. / Yamada, Shunsuke; Tokumoto, Masanori; Taniguchi, Masatomo; Kitada, Hidehisa; Tsuruya, Kazuhiko; Kitazono, Takanari.

In: Clinical Kidney Journal, Vol. 6, No. 4, 2013, p. 429-432.

Research output: Contribution to journalArticle

Yamada, Shunsuke ; Tokumoto, Masanori ; Taniguchi, Masatomo ; Kitada, Hidehisa ; Tsuruya, Kazuhiko ; Kitazono, Takanari. / Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio. In: Clinical Kidney Journal. 2013 ; Vol. 6, No. 4. pp. 429-432.
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