Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio

Shunsuke Yamada; Masanori Tokumoto; Masatomo Taniguchi; Hidehisa Kitada; Kazuhiko Tsuruya; Takanari Kitazono

doi:10.1093/ckj/sft061

Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio

Shunsuke Yamada, Masanori Tokumoto, Masatomo Taniguchi, Hidehisa Kitada, Kazuhiko Tsuruya, Takanari Kitazono

Internal Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A 34-year-old female hemodialysis patient with an abnormal whole parathyroid hormone (PTH)/intact PTH ratio (ratio = 1.14) underwent parathyroidectomy for advanced secondary hyperparathyroidism. The abnormal PTH ratio indicated a relative increase in the serum N-terminus PTH, a new molecular form of PTH. The abnormal ratio normalized immediately after the largest parathyroid gland (PTG) was removed, proving the largest PTG as causative. An immunohistochemical analysis revealed extremely decreased expression of the calcium-sensing receptor and parafibromin in the largest PTG in comparison with the other PTGs. This case indicated the possible involvement of decreased calcium-sensing receptor and parafibromin signaling in the development of the abnormal PTH ratio.

Original language	English (US)
Pages (from-to)	429-432
Number of pages	4
Journal	Clinical Kidney Journal
Volume	6
Issue number	4
DOIs	https://doi.org/10.1093/ckj/sft061
State	Published - Aug 2013

Keywords

N-terminus PTH
calcium-sensing receptor
parafibromin
secondary hyperparathyroidism

ASJC Scopus subject areas

Nephrology
Transplantation

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10.1093/ckj/sft061

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title = "Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio",

abstract = "A 34-year-old female hemodialysis patient with an abnormal whole parathyroid hormone (PTH)/intact PTH ratio (ratio = 1.14) underwent parathyroidectomy for advanced secondary hyperparathyroidism. The abnormal PTH ratio indicated a relative increase in the serum N-terminus PTH, a new molecular form of PTH. The abnormal ratio normalized immediately after the largest parathyroid gland (PTG) was removed, proving the largest PTG as causative. An immunohistochemical analysis revealed extremely decreased expression of the calcium-sensing receptor and parafibromin in the largest PTG in comparison with the other PTGs. This case indicated the possible involvement of decreased calcium-sensing receptor and parafibromin signaling in the development of the abnormal PTH ratio.",

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AU - Yamada, Shunsuke

AU - Tokumoto, Masanori

AU - Taniguchi, Masatomo

AU - Kitada, Hidehisa

AU - Tsuruya, Kazuhiko

AU - Kitazono, Takanari

PY - 2013/8

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AB - A 34-year-old female hemodialysis patient with an abnormal whole parathyroid hormone (PTH)/intact PTH ratio (ratio = 1.14) underwent parathyroidectomy for advanced secondary hyperparathyroidism. The abnormal PTH ratio indicated a relative increase in the serum N-terminus PTH, a new molecular form of PTH. The abnormal ratio normalized immediately after the largest parathyroid gland (PTG) was removed, proving the largest PTG as causative. An immunohistochemical analysis revealed extremely decreased expression of the calcium-sensing receptor and parafibromin in the largest PTG in comparison with the other PTGs. This case indicated the possible involvement of decreased calcium-sensing receptor and parafibromin signaling in the development of the abnormal PTH ratio.

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Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio

Abstract

Keywords

ASJC Scopus subject areas

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