Decreased production of interleukin-12 and interferon-γ is associated with renal involvement in systemic lupus erythematosus

Do June Min, Mi La Cho, Chul Soo Cho, So Youn Min, Wan Uk Kim, Si Young Yang, Jun Ki Min, Yeon Sik Hong, Sang Heon Lee, Sung Hwan Park, Ho Youn Kim

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Objective. To analyze the type 1/type 2 cytokine balance in patients with systemic lupus erythematosus (SLE) according to the presence of renal disorder and activity status. Methods. We measured the serum levels of type 1 (IFN-γ, IL-12) and type 2 cytokines (IL-4, IL-10) as well as spontaneous and stimulated cytokine production from peripheral blood mononuclear cells (PBMC) in 40 patients with SLE. Results. Patients with lupus nephritis (LN) showed significantly lower levels of serum IL-12 and IFN-γ than those without LN. Production of IL-12 and IFN-γ by stimulated PBMC were also decreased in patients with LN. The circulating IL-12 correlated positively with IFN-γ, but inversely with IL-10. The SLEDAI scores correlated well with the ratio of IL-4/IFN-γ levels. Conclusion. The reduced production of IL-12 and IFN-γ and the resultant shift towards the type 2 cytokine phenotype may be associated with LN.

Original languageEnglish (US)
Pages (from-to)159-163
Number of pages5
JournalScandinavian Journal of Rheumatology
Volume30
Issue number3
DOIs
StatePublished - 2001

Keywords

  • Disease activity
  • Interferon-γ
  • Interleukin-12
  • Lupus nephritis
  • Systemic lupus erythematosus
  • Type 2 cytokine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

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