Delayed regional metabolic actions of phencyclidine

Gao Xue-Min Gao, Shirakawa Osamu Shirakawa, Du Fu Du, Carol A. Tamminga

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Phencyclidine (PCP), a psychotomimetic drug of abuse, produces mental changes and manifestations in humans which are reminiscent of schizophrenia, though the mechanism of these actions remains unknown. We report here a biphasic time course of PCP action on regional cerebral glucose metabolism extending over 48 h. A single dose of PCP (8.6 mg/kg) produces an initial increase in glucose metabolism (at 3 h) and a later decrease in glucose metabolism (at 24 h) without a return to baseline until 48 h. A single lower dose of PCP (0.86 mg/kg), a dose which is considered selective for action at the NMDA-PCP receptor, produces no early metabolic change (at 3 h), but replicates the regional hypometabolism albeit less intense at 24 h. The delayed cerebral hypometabolism does not appear to be related to PCP-induced intracellular vacuolization, seen in the retrosplenial cortex. These metabolic changes may be associated with the psychotomimetic effects of PCP and thus may be relevant to psychosis in humans.

Original languageEnglish (US)
Pages (from-to)7-15
Number of pages9
JournalEuropean Journal of Pharmacology
Volume241
Issue number1
DOIs
StatePublished - Sep 7 1993

    Fingerprint

Keywords

  • Glucose metabolism
  • Histopathology
  • Limbic system
  • Phencyclidine
  • Psychosis
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology

Cite this