TY - JOUR
T1 - Demonstration of a macromolecule cross-reacting with antibodies to luteinizing hormone releasing hormone and its tissue distribution
AU - Barnea, Ayalla
AU - Porter, John C.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1975/12/15
Y1 - 1975/12/15
N2 - Hypothalamic cytosol contains a macromolecule which cross-reacts with antibodies to luteinizing hormone releasing hormone (LRH). This cross-reacting material (macro-CRM) is insoluble in methanol or acid ethanol, and its molecular weight is about 70,000. Macro-CRM is also found in cytosols of extra-hypothalamic regions of the brain, liver, kidney, spleen, and skeletal muscle. Plasma contains only marginal amounts of macro-CRM. This substance inhibits the binding of [125I]LRH to LRH antibodies in a reversible, competitive manner.
AB - Hypothalamic cytosol contains a macromolecule which cross-reacts with antibodies to luteinizing hormone releasing hormone (LRH). This cross-reacting material (macro-CRM) is insoluble in methanol or acid ethanol, and its molecular weight is about 70,000. Macro-CRM is also found in cytosols of extra-hypothalamic regions of the brain, liver, kidney, spleen, and skeletal muscle. Plasma contains only marginal amounts of macro-CRM. This substance inhibits the binding of [125I]LRH to LRH antibodies in a reversible, competitive manner.
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U2 - 10.1016/0006-291X(75)90175-8
DO - 10.1016/0006-291X(75)90175-8
M3 - Article
C2 - 1106418
AN - SCOPUS:0016828357
SN - 0006-291X
VL - 67
SP - 1346
EP - 1352
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 4
ER -