Demonstration of a macromolecule cross-reacting with antibodies to luteinizing hormone releasing hormone and its tissue distribution

Ayalla Barnea, John C. Porter

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Hypothalamic cytosol contains a macromolecule which cross-reacts with antibodies to luteinizing hormone releasing hormone (LRH). This cross-reacting material (macro-CRM) is insoluble in methanol or acid ethanol, and its molecular weight is about 70,000. Macro-CRM is also found in cytosols of extra-hypothalamic regions of the brain, liver, kidney, spleen, and skeletal muscle. Plasma contains only marginal amounts of macro-CRM. This substance inhibits the binding of [125I]LRH to LRH antibodies in a reversible, competitive manner.

Original languageEnglish (US)
Pages (from-to)1346-1352
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume67
Issue number4
DOIs
StatePublished - Dec 15 1975

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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