TY - JOUR
T1 - Deptor at the nexus of cancer, metabolism, and immunity
AU - Caron, Alexandre
AU - Briscoe, David M.
AU - Richard, Denis
AU - Laplante, Mathieu
N1 - Funding Information:
de Québec–Université Laval to M. Laplante. A. Caron was a Diabetes Canada Postdoctoral Fellow and is now a CIHR Banting Postdoctoral Fellow. Studies on the function of DEPTOR in inflammation were supported by NIH Grants R21AI114223, R21AI129168, and RO1AI136503 (to D. M. Briscoe).
Funding Information:
This work was supported by grants from the Canadian Institutes of Health Research (MOP374552), the Natural Sciences and Engineering Research Council of Canada (418158 –2012), Les Fonds de Recherche du Québec– Santé (32756), Le Réseau de Recherche en Santé Cardio-Métabolique, Diabète et Obésité, Le Réseau de Bio-Im-agerie du Québec, Diabète Québec, and La Fondation de l’Institut Universitaire de Cardiologie et de Pneumologie
Publisher Copyright:
© 2018 American Physiological Society. All rights reserved.
PY - 2018/6/13
Y1 - 2018/6/13
N2 - DEP domain-containing mechanistic target of rapamycin (mTOR)-interacting protein (DEPTOR) is an important modulator of mTOR, a kinase at the center of two important protein complexes named mTORC1 and mTORC2. These highly studied complexes play essential roles in regulating growth, metabolism, and immunity in response to mitogens, nutrients, and cytokines. Defects in mTOR signaling have been associated with the development of many diseases, including cancer and diabetes, and approaches aiming at modulating mTOR activity are envisioned as an attractive strategy to improve human health. DEPTOR interaction with mTOR represses its kinase activity and rewires the mTOR signaling pathway. Over the last years, several studies have revealed key roles for DEPTOR in numerous biological and pathological processes. Here, we provide the current state of the knowledge regarding the cellular and physiological functions of DEPTOR by focusing on its impact on the mTOR pathway and its role in promoting health and disease.
AB - DEP domain-containing mechanistic target of rapamycin (mTOR)-interacting protein (DEPTOR) is an important modulator of mTOR, a kinase at the center of two important protein complexes named mTORC1 and mTORC2. These highly studied complexes play essential roles in regulating growth, metabolism, and immunity in response to mitogens, nutrients, and cytokines. Defects in mTOR signaling have been associated with the development of many diseases, including cancer and diabetes, and approaches aiming at modulating mTOR activity are envisioned as an attractive strategy to improve human health. DEPTOR interaction with mTOR represses its kinase activity and rewires the mTOR signaling pathway. Over the last years, several studies have revealed key roles for DEPTOR in numerous biological and pathological processes. Here, we provide the current state of the knowledge regarding the cellular and physiological functions of DEPTOR by focusing on its impact on the mTOR pathway and its role in promoting health and disease.
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U2 - 10.1152/physrev.00064.201
DO - 10.1152/physrev.00064.201
M3 - Review article
C2 - 29897294
AN - SCOPUS:85052510174
SN - 0031-9333
VL - 98
SP - 1765
EP - 1803
JO - Physiological reviews
JF - Physiological reviews
IS - 3
ER -