Evaluation des effets cardiovasculaires du liraglutide: conception et donnees de base de l'etude Liraglutide effect and action in diabetes: Evaluation of cardiovascular outcome results (LEADER®)

Translated title of the contribution: Design of the Liraglutide effect and action in diabetes: Evaluation of cardiovascular outcome results (LEADER® trial)

M. Marre, S. P. Marso, N. R. Poulter, S. E. Nissen, M. A. Nauck, B. Zinman, G. H. Daniels, S. Pocock, W. M. Steinberg, R. M. Bergenstal, J. F E Mann, L. Steen Ravn, K. Brown Frandsen, A. C. Moses, J. B. Buse

Research output: Contribution to journalArticle

Abstract

LEADER® (Liraglutide effect and action in diabetes: Evaluation of cardiovascular outcomes results) is a clinical trial evaluating the long-term effect of liraglutide on the incidence of cardiovascular events among 9 340 patients with type 2 diabetes at high cardiovascular risk. The primary endpoint was the occurrence of cardiovascular death, nonfatal myocardial infarction, or stroke. Patients, naive or treated with conventional diabetes therapy, were randomized 1:1 to receive liraglutide or placebo, and followed up to 5 years after randomization. LEADER® design is presented here.

Translated title of the contributionDesign of the Liraglutide effect and action in diabetes: Evaluation of cardiovascular outcome results (LEADER® trial)
Original languageFrench
Pages (from-to)316-328
Number of pages13
JournalMedecine des Maladies Metaboliques
Volume9
Issue number3
DOIs
StatePublished - Jan 1 2015

Keywords

  • GLP-1 receptor agonists
  • Liraglutide
  • cardiovascular.
  • type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Marre, M., Marso, S. P., Poulter, N. R., Nissen, S. E., Nauck, M. A., Zinman, B., Daniels, G. H., Pocock, S., Steinberg, W. M., Bergenstal, R. M., Mann, J. F. E., Steen Ravn, L., Brown Frandsen, K., Moses, A. C., & Buse, J. B. (2015). Evaluation des effets cardiovasculaires du liraglutide: conception et donnees de base de l'etude Liraglutide effect and action in diabetes: Evaluation of cardiovascular outcome results (LEADER®). Medecine des Maladies Metaboliques, 9(3), 316-328. https://doi.org/10.1016/s1957-2557(15)30080-8