Design of the Texas Hepatocellular Carcinoma Consortium Cohort Study

Ziding Feng, Jorge A Marrero, Saira Khaderi, Amit Singal, Fasiha Kanwal, Nicole Loo, Laura Beretta, Jing Ning, Hashem B. El-Serag

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES: The Texas Hepatocellular Carcinoma Consortium cohort study investigates risk factors of hepatocellular carcinoma (HCC) and biomarkers for early HCC detection in patients with liver cirrhosis. METHODS: Adult patients with liver cirrhosis are enrolled at 5 clinical centers from 3 cities in Texas, with a target of 5,000 patients. Clinical history, risk factor questionnaires, liver imaging, laboratory data, and blood samples were collected at enrollment and at each 6-month follow-up visit. RESULTS: The primary outcome was the development of HCC. Biomarkers were tested in banked blood samples using prospective specimen collection, retrospective blinded evaluation design. CONCLUSIONS: We describe study design, eligibility criteria, recruitment, study cores, and sample size and analysis considerations.

Original languageEnglish (US)
Pages (from-to)530-532
Number of pages3
JournalThe American journal of gastroenterology
Volume114
Issue number3
DOIs
StatePublished - Mar 1 2019

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Hepatocellular Carcinoma
Cohort Studies
Liver Cirrhosis
Biomarkers
Specimen Handling
Sample Size
Liver

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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Design of the Texas Hepatocellular Carcinoma Consortium Cohort Study. / Feng, Ziding; Marrero, Jorge A; Khaderi, Saira; Singal, Amit; Kanwal, Fasiha; Loo, Nicole; Beretta, Laura; Ning, Jing; El-Serag, Hashem B.

In: The American journal of gastroenterology, Vol. 114, No. 3, 01.03.2019, p. 530-532.

Research output: Contribution to journalArticle

Feng, Ziding ; Marrero, Jorge A ; Khaderi, Saira ; Singal, Amit ; Kanwal, Fasiha ; Loo, Nicole ; Beretta, Laura ; Ning, Jing ; El-Serag, Hashem B. / Design of the Texas Hepatocellular Carcinoma Consortium Cohort Study. In: The American journal of gastroenterology. 2019 ; Vol. 114, No. 3. pp. 530-532.
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AU - Loo, Nicole

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