Design, synthesis, and molecular modeling studies of 5′-deoxy-5′-ureidoadenosine: 5′-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase

Ting Wang, Hyun Joo Lee, Dilip K. Tosh, Hea Ok Kim, Shantanu Pal, Sun Choi, Yoonji Lee, Hyung Ryong Moon, Long Xuan Zhao, Kang Man Lee, Lak Shin Jeong

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

5′-Deoxy-5′-ureidoadenosine was designed and synthesized as a potent inhibitor of S-adenosylhomocysteine hydrolase (SAH), in which 5′-ureido group acted as multiple hydrogen bonding donor in binding with active site residues of SAH in the molecular modeling study.

Original languageEnglish (US)
Pages (from-to)4456-4459
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number16
DOIs
StatePublished - Aug 15 2007
Externally publishedYes

Keywords

  • 5′-Ureidoadenosine
  • Multiple hydrogen bonding donor
  • S-Adenosylhomocysteine hydrolase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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