Detection of ultrasound-modulated photons and enhancement with ultrasound microbubbles

David J. Hall, Mark J. Hsu, Sadik Esener, Robert F. Mattrey

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In vivo acousto-optic imaging promises to provide optical contrast at superior ultrasound spatial resolution. The main challenge is to detect ultrasound-modulated photons in the overwhelming presence of un-modulated photons. We have demonstrated in vitro detection of ultrasound-modulated photons with a variety of detection methods. Furthermore, we have detected ultrasound-modulated fluorescence offering potential for acousto-optic molecular imaging. Moreover, we have demonstrated the use of ultrasound microbubbles to significantly enhance the acousto-optic signal at the ultrasound frequency with the additional generation of higher order harmonic frequencies. Here the results from our various detection methods, ultrasound-modulated fluorescence, and enhancement with microbubbles are presented.

Original languageEnglish (US)
Article number71771L
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7177
DOIs
StatePublished - Jun 8 2009

Fingerprint

Microbubbles
acousto-optics
Ultrasound
Photons
Photon
Enhancement
Ultrasonics
augmentation
Acousto-optics
photons
Fluorescence
fluorescence
Molecular Imaging
Optics
spatial resolution
harmonics
Imaging
Molecular imaging
Spatial Resolution
Harmonic

Keywords

  • Acousto-optic
  • Fluorescence
  • Microbubbles
  • Ultrasound-modulated photons

ASJC Scopus subject areas

  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Applied Mathematics
  • Condensed Matter Physics

Cite this

Detection of ultrasound-modulated photons and enhancement with ultrasound microbubbles. / Hall, David J.; Hsu, Mark J.; Esener, Sadik; Mattrey, Robert F.

In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 7177, 71771L, 08.06.2009.

Research output: Contribution to journalArticle

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