Determining pattern of recurrence following pancreaticoduodenectomy and adjuvant 5-flurouracil-based chemoradiation therapy: Effect of number of metastatic lymph nodes and lymph node ratio

Bolanle Asiyanbola, Ana Gleisner, Joseph M. Herman, Michael A. Choti, Christopher L. Wolfgang, Michael Swartz, Barish H. Edil, Richard D. Schulick, John L. Cameron, Timothy M. Pawlik

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Abstract

Background: There are limited data on patterns of recurrence and factors associated with local recurrence following pancreaticoduodenectomy for pancreatic adenocarcinoma and adjuvant 5-flurouracil-based chemoradiation therapy. Methods and Materials: Between 1995 and 2005, 905 patients underwent pancreaticoduodenectomy for pancreatic adenocarcinoma; 154 patients had complete pattern of recurrence data available. Results: At median follow-up of 20.2 months, 103 (66.9%) patients recurred with median time to recurrence of 16.2 months. Most patients recurred with distant disease only (68.9%), while 21.4% patients recurred with local disease only; ten (9.7%) patients recurred with local and distant disease. Several factors were associated with local recurrence: poor tumor differentiation (hazards ration [HR] 2.39) and presence of metastatic lymph nodes (HR 1.89, both p∈<∈0.05). Among N1 patients, poor tumor differentiation (HR 3.92), >5 metastatic LN (HR 3.75), and lymph node ratio (LNR) >0.4 (HR 2.96) had the highest risk of local recurrence (all p∈<∈0.05). Increasing LNR was associated with an incremental increased risk of local recurrence (LNR <0.2, 21.3% versus LNR 0.2 to 0.4, 25.2% versus LNR >0.4, 40.4%; p∈<∈0.05). Conclusions: Although most patients who receive standard 5-flurouracil-based chemoradiation therapy will ultimately succumb to distant disease, about 30% recur locally. Poor tumor differentiation, a high number of metastatic LN (>5), and LNR >0.4 are associated with the highest risk of local failure. In these patients, radiation dose escalation and/or a combination of radiation with novel chemotherapeutic agents may be necessary to improve outcomes.

Original languageEnglish (US)
Pages (from-to)752-759
Number of pages8
JournalJournal of Gastrointestinal Surgery
Volume13
Issue number4
DOIs
Publication statusPublished - Apr 2009

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Keywords

  • 5-Flurouracil
  • Adenocarcinoma
  • Adjuvant chemoradiation
  • Lymph node
  • Pancreatic
  • Recurrence

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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