Development and prevention of morphologic and ultrastructural changes in uremia-induced hyperplastic parathyroid gland

Kazuhiro Shiizaki, Ikuji Hatamura, Masao Mato, Eiko Nakazawa, Fumie Saji, Akira Onishi, Manabu Ogura, Yuko Watanabe, Eiji Kusano

Research output: Contribution to journalArticle

Abstract

The detailed ultrastructural changes of uremia-induced hyperplastic parathyroid gland and the effects of current medical treatments for secondary hyperparathyroidism were investigated. Marked enlargement of parathyroid cell with accumulation of mitochondria and lipids and a significant increase in the thickness of the pericapillary area with increased fibrosis and appearance of fibroblast like cells were noted in the hyperplastic gland caused by uremia and phosphate retention. These ultrastructural changes and biochemical findings indicating hyperparathyroidism were significantly suppressed by all of the treatment using phosphate restriction, calcitriol, and cinacalcet. The characteristic ultrastructural changes, including the morphologic evidence of nodule formation, were indicated.

Original languageEnglish (US)
Pages (from-to)230-238
Number of pages9
JournalUltrastructural Pathology
Volume35
Issue number5
DOIs
StatePublished - Oct 1 2011

Keywords

  • chronic renal failure
  • electron microscopy
  • hyperparathyroidism
  • morphometry
  • parathyroid hyperplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology

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  • Cite this

    Shiizaki, K., Hatamura, I., Mato, M., Nakazawa, E., Saji, F., Onishi, A., Ogura, M., Watanabe, Y., & Kusano, E. (2011). Development and prevention of morphologic and ultrastructural changes in uremia-induced hyperplastic parathyroid gland. Ultrastructural Pathology, 35(5), 230-238. https://doi.org/10.3109/01913123.2011.601406