Development and prevention of morphologic and ultrastructural changes in uremia-induced hyperplastic parathyroid gland

Kazuhiro Shiizaki; Ikuji Hatamura; Masao Mato; Eiko Nakazawa; Fumie Saji; Akira Onishi; Manabu Ogura; Yuko Watanabe; Eiji Kusano

doi:10.3109/01913123.2011.601406

Development and prevention of morphologic and ultrastructural changes in uremia-induced hyperplastic parathyroid gland

Kazuhiro Shiizaki, Ikuji Hatamura, Masao Mato, Eiko Nakazawa, Fumie Saji, Akira Onishi, Manabu Ogura, Yuko Watanabe, Eiji Kusano

Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

The detailed ultrastructural changes of uremia-induced hyperplastic parathyroid gland and the effects of current medical treatments for secondary hyperparathyroidism were investigated. Marked enlargement of parathyroid cell with accumulation of mitochondria and lipids and a significant increase in the thickness of the pericapillary area with increased fibrosis and appearance of fibroblast like cells were noted in the hyperplastic gland caused by uremia and phosphate retention. These ultrastructural changes and biochemical findings indicating hyperparathyroidism were significantly suppressed by all of the treatment using phosphate restriction, calcitriol, and cinacalcet. The characteristic ultrastructural changes, including the morphologic evidence of nodule formation, were indicated.

Original language	English (US)
Pages (from-to)	230-238
Number of pages	9
Journal	Ultrastructural Pathology
Volume	35
Issue number	5
DOIs	https://doi.org/10.3109/01913123.2011.601406
State	Published - Oct 2011

Keywords

chronic renal failure
electron microscopy
hyperparathyroidism
morphometry
parathyroid hyperplasia

ASJC Scopus subject areas

Pathology and Forensic Medicine
Structural Biology

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10.3109/01913123.2011.601406

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title = "Development and prevention of morphologic and ultrastructural changes in uremia-induced hyperplastic parathyroid gland",

abstract = "The detailed ultrastructural changes of uremia-induced hyperplastic parathyroid gland and the effects of current medical treatments for secondary hyperparathyroidism were investigated. Marked enlargement of parathyroid cell with accumulation of mitochondria and lipids and a significant increase in the thickness of the pericapillary area with increased fibrosis and appearance of fibroblast like cells were noted in the hyperplastic gland caused by uremia and phosphate retention. These ultrastructural changes and biochemical findings indicating hyperparathyroidism were significantly suppressed by all of the treatment using phosphate restriction, calcitriol, and cinacalcet. The characteristic ultrastructural changes, including the morphologic evidence of nodule formation, were indicated.",

keywords = "chronic renal failure, electron microscopy, hyperparathyroidism, morphometry, parathyroid hyperplasia",

author = "Kazuhiro Shiizaki and Ikuji Hatamura and Masao Mato and Eiko Nakazawa and Fumie Saji and Akira Onishi and Manabu Ogura and Yuko Watanabe and Eiji Kusano",

note = "Funding Information: Received 14 June 2011; revised 18 June 2011; accepted 20 June 2011 The authors would thank Takashi Yashiro and Tomi Kouki (Core Microscopy Facility, Jichi Medical University) for their technical assistance. This study was supported in part by a grant from the Kidney Foundation, Japan (Grant no. JKFB08-32). Correspondence: Kazuhiro Shiizaki, MD, PhD, Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan. E-mail: shiizaki@jichi.ac.jp Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",

year = "2011",

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doi = "10.3109/01913123.2011.601406",

language = "English (US)",

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AU - Saji, Fumie

AU - Onishi, Akira

AU - Ogura, Manabu

AU - Watanabe, Yuko

AU - Kusano, Eiji

N1 - Funding Information: Received 14 June 2011; revised 18 June 2011; accepted 20 June 2011 The authors would thank Takashi Yashiro and Tomi Kouki (Core Microscopy Facility, Jichi Medical University) for their technical assistance. This study was supported in part by a grant from the Kidney Foundation, Japan (Grant no. JKFB08-32). Correspondence: Kazuhiro Shiizaki, MD, PhD, Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan. E-mail: shiizaki@jichi.ac.jp Copyright: Copyright 2012 Elsevier B.V., All rights reserved.

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Development and prevention of morphologic and ultrastructural changes in uremia-induced hyperplastic parathyroid gland

Abstract

Keywords

ASJC Scopus subject areas

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