Development and Validation of a Novel Scoring System for Predicting Technical Success of Chronic Total Occlusion Percutaneous Coronary Interventions the PROGRESS CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention) Score

Georgios Christopoulos, David E. Kandzari, Robert W. Yeh, Farouc A. Jaffer, Dimitri Karmpaliotis, Michael R. Wyman, Khaldoon Alaswad, William Lombardi, J. Aaron Grantham, Jeffrey Moses, Georgios Christakopoulos, Muhammad Nauman J Tarar, Bavana V. Rangan, Nicholas Lembo, Santiago Garcia, Daisha Cipher, Craig A. Thompson, Subhash Banerjee, Emmanouil S. Brilakis

Research output: Contribution to journalArticle

111 Scopus citations


Objectives This study sought to develop a novel parsimonious score for predicting technical success of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) performed using the hybrid approach. Background Predicting technical success of CTO PCI can facilitate clinical decision making and procedural planning. Methods We analyzed clinical and angiographic parameters from 781 CTO PCIs included in PROGRESS CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention) using a derivation and validation cohort (2:1 sampling ratio). Variables with strong association with technical success in multivariable analysis were assigned 1 point, and a 4-point score was developed from summing all points. The PROGRESS CTO score was subsequently compared with the J-CTO (Multicenter Chronic Total Occlusion Registry in Japan) score in the validation cohort. Results Technical success was 92.9%. On multivariable analysis, factors associated with technical success included proximal cap ambiguity (beta coefficient [b] = 0.88), moderate/severe tortuosity (b = 1.18), circumflex artery CTO (b = 0.99), and absence of "interventional" collaterals (b = 0.88). The resulting score demonstrated good calibration and discriminatory capacity in the derivation (Hosmer-Lemeshow chi-square = 2.633; p = 0.268, and receiver-operator characteristic [ROC] area = 0.778) and validation (Hosmer-Lemeshow chi-square = 5.333; p = 0.070, and ROC area = 0.720) subset. In the validation cohort, the PROGRESS CTO and J-CTO scores performed similarly in predicting technical success (ROC area 0.720 vs. 0.746, area under the curve difference = 0.026, 95% confidence interval = -0.093 to 0.144). Conclusions The PROGRESS CTO score is a novel useful tool for estimating technical success in CTO PCI performed using the hybrid approach.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalJACC: Cardiovascular Interventions
Issue number1
Publication statusPublished - Jan 11 2016



  • chronic total occlusion
  • percutaneous coronary intervention
  • scoring
  • technical success

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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