Development of cholinergic neurons in the septal/diagonal band complex of the rat

David M. Armstrong, Gordon Bruce, Louis B. Hersh, Fred H. Gage

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

In the present study we employed immunohistochemical techniques using a polyclonal antibody against choline acetyltransferase (ChAT) to determine the distribution and cytological features of cholinergic neurons in the developing septal/diagonal band complex of the rat. ChAT-positive perikarya were first clearly detected in this region on embryonic day 17, although the neurons were faintly labeled and lacked the cytological details found in the adult. After birth we observed a dramatic increase in the intensity of the immunolabeling which continued until postnatal day 23. Thereafter, the ChAT-positive neurons assumed their adult-like characteristics.

Original languageEnglish (US)
Pages (from-to)249-256
Number of pages8
JournalDevelopmental Brain Research
Volume36
Issue number2
DOIs
StatePublished - Dec 1 1987

Keywords

  • Choline acetyltransferase
  • Development
  • Immunocytochemistry
  • Rat
  • Septal/diagonal band

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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