These results show a dissociation between the abilities of serum and brain homogenates to degrade synthetic TRH. In young rats, the inactivation rate of TRH is low in serum, but high in the brain, and after day 14 of life, TRH degrading activity in the serum increases whereas that in the brain decreases. The physiological role of these age-related changes in the degradation of TRH remains to be established.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism