Developmental changes in the degradation of thyrotrophin releasing hormone by the serum and brain tissues of the male rat

C. Oliver; C. R. Parker; J. C. Porter

doi:10.1677/joe.0.0740339

Developmental changes in the degradation of thyrotrophin releasing hormone by the serum and brain tissues of the male rat

C. Oliver, C. R. Parker, J. C. Porter

Obstetrics & Gynecology

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30 Scopus citations

Abstract

These results show a dissociation between the abilities of serum and brain homogenates to degrade synthetic TRH. In young rats, the inactivation rate of TRH is low in serum, but high in the brain, and after day 14 of life, TRH degrading activity in the serum increases whereas that in the brain decreases. The physiological role of these age-related changes in the degradation of TRH remains to be established.

Original language	English (US)
Pages (from-to)	339-340
Number of pages	2
Journal	Journal of Endocrinology
Volume	74
Issue number	2
DOIs	https://doi.org/10.1677/joe.0.0740339
State	Published - 1977

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1677/joe.0.0740339

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abstract = "These results show a dissociation between the abilities of serum and brain homogenates to degrade synthetic TRH. In young rats, the inactivation rate of TRH is low in serum, but high in the brain, and after day 14 of life, TRH degrading activity in the serum increases whereas that in the brain decreases. The physiological role of these age-related changes in the degradation of TRH remains to be established.",

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Developmental changes in the degradation of thyrotrophin releasing hormone by the serum and brain tissues of the male rat

Abstract

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