Dextromethorphan for treatment of complex partial seizures

R. S. Fisher, B. J. Cysyk, R. P. Lesser, M. J. Pontecorvo, J. T. Ferkany, P. R. Schwerdt, J. Hart, B. Gordon

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

We performed a double-blind, crossover, add-on study of the antitussive agent dextromethorphan (DM 120 mg/d) as therapy for seizures on 9 patients suffering from severe complex partial seizures. DM had no significant influence on key laboratory values, nor on anticonvulsant drug levels. Side effects were negligible. Complex partial seizure frequency increased 25% during the DM arm of the study, although this increase was not clinically significant.

Original languageEnglish (US)
Pages (from-to)547-549
Number of pages3
JournalNeurology
Volume40
Issue number3
StatePublished - Mar 1990

Fingerprint

Dextromethorphan
Seizures
Antitussive Agents
Anticonvulsants
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fisher, R. S., Cysyk, B. J., Lesser, R. P., Pontecorvo, M. J., Ferkany, J. T., Schwerdt, P. R., ... Gordon, B. (1990). Dextromethorphan for treatment of complex partial seizures. Neurology, 40(3), 547-549.

Dextromethorphan for treatment of complex partial seizures. / Fisher, R. S.; Cysyk, B. J.; Lesser, R. P.; Pontecorvo, M. J.; Ferkany, J. T.; Schwerdt, P. R.; Hart, J.; Gordon, B.

In: Neurology, Vol. 40, No. 3, 03.1990, p. 547-549.

Research output: Contribution to journalArticle

Fisher, RS, Cysyk, BJ, Lesser, RP, Pontecorvo, MJ, Ferkany, JT, Schwerdt, PR, Hart, J & Gordon, B 1990, 'Dextromethorphan for treatment of complex partial seizures', Neurology, vol. 40, no. 3, pp. 547-549.
Fisher RS, Cysyk BJ, Lesser RP, Pontecorvo MJ, Ferkany JT, Schwerdt PR et al. Dextromethorphan for treatment of complex partial seizures. Neurology. 1990 Mar;40(3):547-549.
Fisher, R. S. ; Cysyk, B. J. ; Lesser, R. P. ; Pontecorvo, M. J. ; Ferkany, J. T. ; Schwerdt, P. R. ; Hart, J. ; Gordon, B. / Dextromethorphan for treatment of complex partial seizures. In: Neurology. 1990 ; Vol. 40, No. 3. pp. 547-549.
@article{db27731b166d4973953f589e6ce353c1,
title = "Dextromethorphan for treatment of complex partial seizures",
abstract = "We performed a double-blind, crossover, add-on study of the antitussive agent dextromethorphan (DM 120 mg/d) as therapy for seizures on 9 patients suffering from severe complex partial seizures. DM had no significant influence on key laboratory values, nor on anticonvulsant drug levels. Side effects were negligible. Complex partial seizure frequency increased 25{\%} during the DM arm of the study, although this increase was not clinically significant.",
author = "Fisher, {R. S.} and Cysyk, {B. J.} and Lesser, {R. P.} and Pontecorvo, {M. J.} and Ferkany, {J. T.} and Schwerdt, {P. R.} and J. Hart and B. Gordon",
year = "1990",
month = "3",
language = "English (US)",
volume = "40",
pages = "547--549",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Dextromethorphan for treatment of complex partial seizures

AU - Fisher, R. S.

AU - Cysyk, B. J.

AU - Lesser, R. P.

AU - Pontecorvo, M. J.

AU - Ferkany, J. T.

AU - Schwerdt, P. R.

AU - Hart, J.

AU - Gordon, B.

PY - 1990/3

Y1 - 1990/3

N2 - We performed a double-blind, crossover, add-on study of the antitussive agent dextromethorphan (DM 120 mg/d) as therapy for seizures on 9 patients suffering from severe complex partial seizures. DM had no significant influence on key laboratory values, nor on anticonvulsant drug levels. Side effects were negligible. Complex partial seizure frequency increased 25% during the DM arm of the study, although this increase was not clinically significant.

AB - We performed a double-blind, crossover, add-on study of the antitussive agent dextromethorphan (DM 120 mg/d) as therapy for seizures on 9 patients suffering from severe complex partial seizures. DM had no significant influence on key laboratory values, nor on anticonvulsant drug levels. Side effects were negligible. Complex partial seizure frequency increased 25% during the DM arm of the study, although this increase was not clinically significant.

UR - http://www.scopus.com/inward/record.url?scp=0025253528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025253528&partnerID=8YFLogxK

M3 - Article

C2 - 2314601

AN - SCOPUS:0025253528

VL - 40

SP - 547

EP - 549

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 3

ER -