Dextromethorphan for treatment of complex partial seizures

R. S. Fisher, B. J. Cysyk, R. P. Lesser, M. J. Pontecorvo, J. T. Ferkany, P. R. Schwerdt, J. Hart, B. Gordon

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


We performed a double-blind, crossover, add-on study of the antitussive agent dextromethorphan (DM 120 mg/d) as therapy for seizures on 9 patients suffering from severe complex partial seizures. DM had no significant influence on key laboratory values, nor on anticonvulsant drug levels. Side effects were negligible. Complex partial seizure frequency increased 25% during the DM arm of the study, although this increase was not clinically significant.

Original languageEnglish (US)
Pages (from-to)547-549
Number of pages3
Issue number3
StatePublished - Mar 1990

ASJC Scopus subject areas

  • Clinical Neurology


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