DFNB44, a novel autosomal recessive non-syndromic hearing impairment locus, maps to chromosome 7p14.1-q11.22

Muhammad Ansar, Maria H. Chahrour, Mohammad Amin Ud Din, Muhammad Arshad, Sayedul Haque, Thanh L. Pham, Kai Yan, Wasim Ahmad, Suzanne M. Leal

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The genetic etiology for many forms of hearing impairment (HI) is very diverse. Non-syndromic HI (NSHI) is one of the most heterogeneous traits known. Autosomal recessive forms of prelingual HI account for ∼75% of hereditary cases. A novel autosomal recessive NSHI locus, DFNB44, was mapped to a 20.9 cM genetic interval on chromosome 7p14.1-q11.22, according to the Marshfield genetic map, in a consanguineous Pakistani family. Multipoint linkage analysis resulted in a maximum LOD score of 5.0 at marker D7S1818. The 3-unit support interval ranged from marker D7S2209 to marker D7S2435, spanning a 30.1 Mb region on the sequence-based physical map.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
JournalHuman Heredity
Volume57
Issue number4
DOIs
StatePublished - 2004

Keywords

  • 7p14.1-q11.22
  • DFNB44
  • Non-syndromic hearing impairment
  • Pakistan

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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