Dietary fish oil supplementation has no beneficial effects on prevention of diabetes in the spontaneously diabetic (BB/W) rat

R. Kitoh, J. Rosenstock, Philip Raskin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effect of dietary fish oils on the incidence of diabetes was studied in the spontaneously diabetic BB/W rat. Two groups of age, sex and litter matched BB/W rats received isocaloric diets that were either fish oil supplemented (16.7% EPA and 12% DHA), or corn oil supplemented (65% linoleic acid) from 25-35 days of age until termination of the study. There were no differences in the incidence of diabetes between the two groups of rats. Sixty-eight percent of the rats fed the fish oil diet became diabetic, and 63% of the corn oil fed rats became diabetic. Thus, our data failed to show any protective effect of omega-3 polyunsaturated fatty acids on the development of diabetes in these animals. Considering these experimental results, rats may not be an appropriate model for studying effects of omega-3 polyunsaturated fatty acids in an eicosapentaenoic system related disorder. In studying fish oils and their potential effects in humans, we must be careful in interpreting the results from animal models.

Original languageEnglish (US)
Pages (from-to)131-135
Number of pages5
JournalDiabetes, Nutrition and Metabolism - Clinical and Experimental
Volume3
Issue number2
StatePublished - 1990

Fingerprint

Inbred BB Rats
Unsaturated Dietary Fats
Fish Oils
fish oils
diabetes
Corn Oil
rats
Omega-3 Fatty Acids
Unsaturated Fatty Acids
Diabetic Diet
corn oil
omega-3 fatty acids
Incidence
Linoleic Acid
diabetic diet
incidence
Animal Models
Age Groups
Diet
protective effect

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Internal Medicine
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

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title = "Dietary fish oil supplementation has no beneficial effects on prevention of diabetes in the spontaneously diabetic (BB/W) rat",
abstract = "The effect of dietary fish oils on the incidence of diabetes was studied in the spontaneously diabetic BB/W rat. Two groups of age, sex and litter matched BB/W rats received isocaloric diets that were either fish oil supplemented (16.7{\%} EPA and 12{\%} DHA), or corn oil supplemented (65{\%} linoleic acid) from 25-35 days of age until termination of the study. There were no differences in the incidence of diabetes between the two groups of rats. Sixty-eight percent of the rats fed the fish oil diet became diabetic, and 63{\%} of the corn oil fed rats became diabetic. Thus, our data failed to show any protective effect of omega-3 polyunsaturated fatty acids on the development of diabetes in these animals. Considering these experimental results, rats may not be an appropriate model for studying effects of omega-3 polyunsaturated fatty acids in an eicosapentaenoic system related disorder. In studying fish oils and their potential effects in humans, we must be careful in interpreting the results from animal models.",
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AU - Rosenstock, J.

AU - Raskin, Philip

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N2 - The effect of dietary fish oils on the incidence of diabetes was studied in the spontaneously diabetic BB/W rat. Two groups of age, sex and litter matched BB/W rats received isocaloric diets that were either fish oil supplemented (16.7% EPA and 12% DHA), or corn oil supplemented (65% linoleic acid) from 25-35 days of age until termination of the study. There were no differences in the incidence of diabetes between the two groups of rats. Sixty-eight percent of the rats fed the fish oil diet became diabetic, and 63% of the corn oil fed rats became diabetic. Thus, our data failed to show any protective effect of omega-3 polyunsaturated fatty acids on the development of diabetes in these animals. Considering these experimental results, rats may not be an appropriate model for studying effects of omega-3 polyunsaturated fatty acids in an eicosapentaenoic system related disorder. In studying fish oils and their potential effects in humans, we must be careful in interpreting the results from animal models.

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