Dietary restriction increases hippocampal neurogenesis by molecular mechanisms independent of NMDA receptors

Takashi Kitamura, Masayoshi Mishina, Hiroyuki Sugiyama

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Neurogenesis occurs in the adult hippocampus and is promoted by various stimulatory factors, such as enriched environments, running exercises, learning and dietary restriction. We have previously shown that the promotion of adult neurogenesis in the hippocampus by running wheel exercise is mediated by NMDA receptors. In the present study, we report that dietary restriction enhanced the hippocampal neurogenesis in mice lacking NMDA receptor ε1 subunit as well as wile-type mice. This result suggests that the molecular mechanism by which dietary restriction promotes adult neurogenesis may be, in contrast to that of running exercise, independent on the NMDA receptor functions.

Original languageEnglish (US)
Pages (from-to)94-96
Number of pages3
JournalNeuroscience Letters
Volume393
Issue number2-3
DOIs
StatePublished - Jan 30 2006

Keywords

  • BrdU
  • Dietary restriction
  • Exercise
  • Hippocampus
  • NMDA receptor
  • Neurogenesis

ASJC Scopus subject areas

  • Neuroscience(all)

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