Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: A cardiovascular magnetic resonance study

Hunter R. Underhill, Chun Yuan, James G. Terry, Haiying Chen, Mark A. Espeland, Thomas S. Hatsukami, Tobias Saam, Baocheng Chu, Wei Yu, Minako Oikawa, Norihide Takaya, Vasily L. Yarnykh, Robert Kraft, J. Jeffrey Carr, Joseph Maldjian, Rong Tang, John R. Crouse

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Abstract

Objective: We sought to determine differences with cardiovascular magnetic resonance (CMR) in the morphology and composition of the carotid arteries between individuals with angiographically-defined obstructive coronary artery disease (CAD, ≥ 50% stenosis, cases) and those with angiographically normal coronaries (no lumen irregularities, controls). Methods and results: 191 participants (50.3% female; 50.8% CAD cases) were imaged with a multi-sequence, carotid CMR protocol at 1.5T. For each segment of the carotid, lumen area, wall area, total vessel area (lumen area + wall area), mean wall thickness and the presence or absence of calcification and lipid-rich necrotic core were recorded bilaterally. In male CAD cases compared to male controls, the distal bulb had a significantly smaller lumen area (60.0 ± 3.1 vs. 79.7 ± 3.2 mm2, p < 0.001) and total vessel area (99.6 ± 4.0 vs. 119.8 ± 4.1 mm2; p < 0.001), and larger mean wall thickness (1.25 ± 0.03 vs. 1.11 ± 0.03 mm; p = 0.002). Similarly, the internal carotid had a smaller lumen area (37.5 ± 1.8 vs. 44.6 ± 1.8 mm2; p = 0.006) and smaller total vessel area (64.0 ± 2.3 vs. 70.9 ± 2.4 mm2; p = 0.04). These metrics were not significantly different between female groups in the distal bulb and internal carotid or for either gender in the common carotid. Male CAD cases had an increased prevalence of lipid-rich necrotic core (49.0% vs. 19.6%; p = 0.003), while calcification was more prevalent in both male (46.9% vs. 17.4%; p = 0.002) and female (33.3% vs. 14.6%; p = 0.031) CAD cases compared to controls. Conclusion: Males with obstructive CAD compared to male controls had carotid bulbs and internal carotid arteries with smaller total vessel and lumen areas, and an increased prevalence of lipid-rich necrotic core. Carotid calcification was related to CAD status in both males and females. Carotid CMR identifies distinct morphological and compositional differences in the carotid arteries between individuals with and without angiographically-defined obstructive CAD.

Original languageEnglish (US)
Article number31
JournalJournal of Cardiovascular Magnetic Resonance
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2008

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Coronary Artery Disease
Magnetic Resonance Spectroscopy
Pathologic Constriction
Lipids
Carotid Arteries
Internal Carotid Artery

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine
  • Family Practice

Cite this

Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease : A cardiovascular magnetic resonance study. / Underhill, Hunter R.; Yuan, Chun; Terry, James G.; Chen, Haiying; Espeland, Mark A.; Hatsukami, Thomas S.; Saam, Tobias; Chu, Baocheng; Yu, Wei; Oikawa, Minako; Takaya, Norihide; Yarnykh, Vasily L.; Kraft, Robert; Carr, J. Jeffrey; Maldjian, Joseph; Tang, Rong; Crouse, John R.

In: Journal of Cardiovascular Magnetic Resonance, Vol. 10, No. 1, 31, 01.12.2008.

Research output: Contribution to journalArticle

Underhill, HR, Yuan, C, Terry, JG, Chen, H, Espeland, MA, Hatsukami, TS, Saam, T, Chu, B, Yu, W, Oikawa, M, Takaya, N, Yarnykh, VL, Kraft, R, Carr, JJ, Maldjian, J, Tang, R & Crouse, JR 2008, 'Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: A cardiovascular magnetic resonance study', Journal of Cardiovascular Magnetic Resonance, vol. 10, no. 1, 31. https://doi.org/10.1186/1532-429X-10-31
Underhill, Hunter R. ; Yuan, Chun ; Terry, James G. ; Chen, Haiying ; Espeland, Mark A. ; Hatsukami, Thomas S. ; Saam, Tobias ; Chu, Baocheng ; Yu, Wei ; Oikawa, Minako ; Takaya, Norihide ; Yarnykh, Vasily L. ; Kraft, Robert ; Carr, J. Jeffrey ; Maldjian, Joseph ; Tang, Rong ; Crouse, John R. / Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease : A cardiovascular magnetic resonance study. In: Journal of Cardiovascular Magnetic Resonance. 2008 ; Vol. 10, No. 1.
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abstract = "Objective: We sought to determine differences with cardiovascular magnetic resonance (CMR) in the morphology and composition of the carotid arteries between individuals with angiographically-defined obstructive coronary artery disease (CAD, ≥ 50{\%} stenosis, cases) and those with angiographically normal coronaries (no lumen irregularities, controls). Methods and results: 191 participants (50.3{\%} female; 50.8{\%} CAD cases) were imaged with a multi-sequence, carotid CMR protocol at 1.5T. For each segment of the carotid, lumen area, wall area, total vessel area (lumen area + wall area), mean wall thickness and the presence or absence of calcification and lipid-rich necrotic core were recorded bilaterally. In male CAD cases compared to male controls, the distal bulb had a significantly smaller lumen area (60.0 ± 3.1 vs. 79.7 ± 3.2 mm2, p < 0.001) and total vessel area (99.6 ± 4.0 vs. 119.8 ± 4.1 mm2; p < 0.001), and larger mean wall thickness (1.25 ± 0.03 vs. 1.11 ± 0.03 mm; p = 0.002). Similarly, the internal carotid had a smaller lumen area (37.5 ± 1.8 vs. 44.6 ± 1.8 mm2; p = 0.006) and smaller total vessel area (64.0 ± 2.3 vs. 70.9 ± 2.4 mm2; p = 0.04). These metrics were not significantly different between female groups in the distal bulb and internal carotid or for either gender in the common carotid. Male CAD cases had an increased prevalence of lipid-rich necrotic core (49.0{\%} vs. 19.6{\%}; p = 0.003), while calcification was more prevalent in both male (46.9{\%} vs. 17.4{\%}; p = 0.002) and female (33.3{\%} vs. 14.6{\%}; p = 0.031) CAD cases compared to controls. Conclusion: Males with obstructive CAD compared to male controls had carotid bulbs and internal carotid arteries with smaller total vessel and lumen areas, and an increased prevalence of lipid-rich necrotic core. Carotid calcification was related to CAD status in both males and females. Carotid CMR identifies distinct morphological and compositional differences in the carotid arteries between individuals with and without angiographically-defined obstructive CAD.",
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T1 - Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease

T2 - A cardiovascular magnetic resonance study

AU - Underhill, Hunter R.

AU - Yuan, Chun

AU - Terry, James G.

AU - Chen, Haiying

AU - Espeland, Mark A.

AU - Hatsukami, Thomas S.

AU - Saam, Tobias

AU - Chu, Baocheng

AU - Yu, Wei

AU - Oikawa, Minako

AU - Takaya, Norihide

AU - Yarnykh, Vasily L.

AU - Kraft, Robert

AU - Carr, J. Jeffrey

AU - Maldjian, Joseph

AU - Tang, Rong

AU - Crouse, John R.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Objective: We sought to determine differences with cardiovascular magnetic resonance (CMR) in the morphology and composition of the carotid arteries between individuals with angiographically-defined obstructive coronary artery disease (CAD, ≥ 50% stenosis, cases) and those with angiographically normal coronaries (no lumen irregularities, controls). Methods and results: 191 participants (50.3% female; 50.8% CAD cases) were imaged with a multi-sequence, carotid CMR protocol at 1.5T. For each segment of the carotid, lumen area, wall area, total vessel area (lumen area + wall area), mean wall thickness and the presence or absence of calcification and lipid-rich necrotic core were recorded bilaterally. In male CAD cases compared to male controls, the distal bulb had a significantly smaller lumen area (60.0 ± 3.1 vs. 79.7 ± 3.2 mm2, p < 0.001) and total vessel area (99.6 ± 4.0 vs. 119.8 ± 4.1 mm2; p < 0.001), and larger mean wall thickness (1.25 ± 0.03 vs. 1.11 ± 0.03 mm; p = 0.002). Similarly, the internal carotid had a smaller lumen area (37.5 ± 1.8 vs. 44.6 ± 1.8 mm2; p = 0.006) and smaller total vessel area (64.0 ± 2.3 vs. 70.9 ± 2.4 mm2; p = 0.04). These metrics were not significantly different between female groups in the distal bulb and internal carotid or for either gender in the common carotid. Male CAD cases had an increased prevalence of lipid-rich necrotic core (49.0% vs. 19.6%; p = 0.003), while calcification was more prevalent in both male (46.9% vs. 17.4%; p = 0.002) and female (33.3% vs. 14.6%; p = 0.031) CAD cases compared to controls. Conclusion: Males with obstructive CAD compared to male controls had carotid bulbs and internal carotid arteries with smaller total vessel and lumen areas, and an increased prevalence of lipid-rich necrotic core. Carotid calcification was related to CAD status in both males and females. Carotid CMR identifies distinct morphological and compositional differences in the carotid arteries between individuals with and without angiographically-defined obstructive CAD.

AB - Objective: We sought to determine differences with cardiovascular magnetic resonance (CMR) in the morphology and composition of the carotid arteries between individuals with angiographically-defined obstructive coronary artery disease (CAD, ≥ 50% stenosis, cases) and those with angiographically normal coronaries (no lumen irregularities, controls). Methods and results: 191 participants (50.3% female; 50.8% CAD cases) were imaged with a multi-sequence, carotid CMR protocol at 1.5T. For each segment of the carotid, lumen area, wall area, total vessel area (lumen area + wall area), mean wall thickness and the presence or absence of calcification and lipid-rich necrotic core were recorded bilaterally. In male CAD cases compared to male controls, the distal bulb had a significantly smaller lumen area (60.0 ± 3.1 vs. 79.7 ± 3.2 mm2, p < 0.001) and total vessel area (99.6 ± 4.0 vs. 119.8 ± 4.1 mm2; p < 0.001), and larger mean wall thickness (1.25 ± 0.03 vs. 1.11 ± 0.03 mm; p = 0.002). Similarly, the internal carotid had a smaller lumen area (37.5 ± 1.8 vs. 44.6 ± 1.8 mm2; p = 0.006) and smaller total vessel area (64.0 ± 2.3 vs. 70.9 ± 2.4 mm2; p = 0.04). These metrics were not significantly different between female groups in the distal bulb and internal carotid or for either gender in the common carotid. Male CAD cases had an increased prevalence of lipid-rich necrotic core (49.0% vs. 19.6%; p = 0.003), while calcification was more prevalent in both male (46.9% vs. 17.4%; p = 0.002) and female (33.3% vs. 14.6%; p = 0.031) CAD cases compared to controls. Conclusion: Males with obstructive CAD compared to male controls had carotid bulbs and internal carotid arteries with smaller total vessel and lumen areas, and an increased prevalence of lipid-rich necrotic core. Carotid calcification was related to CAD status in both males and females. Carotid CMR identifies distinct morphological and compositional differences in the carotid arteries between individuals with and without angiographically-defined obstructive CAD.

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