Differential activation on fMRI of monozygotic twins discordant for AD

A. M. Lipton, R. McColl, C. M. Cullum, G. Allen, W. K. Ringe, F. J. Bonte, E. McDonald, C. D. Rubin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This is the first report of fMRI in monozygotic twins discordant for AD. FMRI brain activation patterns were examined during visuospatial and verbal working memory tasks. The affected twin had greater parietal involvement bilaterally during both working memory tasks and reduced left dorsolateral prefrontal cortex activity on the visuospatial memory task. Thus, fMRI may identify additional brain regions recruited in patients with AD to perform a given cognitive task.

Original languageEnglish (US)
Pages (from-to)1713-1716
Number of pages4
JournalNeurology
Volume60
Issue number10
StatePublished - May 27 2003

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Monozygotic Twins
Short-Term Memory
Magnetic Resonance Imaging
Brain
Prefrontal Cortex

ASJC Scopus subject areas

  • Neuroscience(all)

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Differential activation on fMRI of monozygotic twins discordant for AD. / Lipton, A. M.; McColl, R.; Cullum, C. M.; Allen, G.; Ringe, W. K.; Bonte, F. J.; McDonald, E.; Rubin, C. D.

In: Neurology, Vol. 60, No. 10, 27.05.2003, p. 1713-1716.

Research output: Contribution to journalArticle

Lipton, AM, McColl, R, Cullum, CM, Allen, G, Ringe, WK, Bonte, FJ, McDonald, E & Rubin, CD 2003, 'Differential activation on fMRI of monozygotic twins discordant for AD', Neurology, vol. 60, no. 10, pp. 1713-1716.
Lipton, A. M. ; McColl, R. ; Cullum, C. M. ; Allen, G. ; Ringe, W. K. ; Bonte, F. J. ; McDonald, E. ; Rubin, C. D. / Differential activation on fMRI of monozygotic twins discordant for AD. In: Neurology. 2003 ; Vol. 60, No. 10. pp. 1713-1716.
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