Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder

Patrick N. Augustyniak, Said Kourrich, Shohreh M. Rezazadeh, Jane Stewart, Andreas Arvanitogiannis

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

We used a putative animal model of attention deficit hyperactivity disorder (ADHD), the SHR rat, to examine the effects of repeated exposure to methylphenidate (MPH; Ritalin®) during the pubertal period on cocaine-induced conditioned place preference and dopamine (DA) levels in the nucleus accumbens (NAc) in adulthood. Our results indicate that early exposure to methylphenidate diminishes sensitivity to the incentive properties of cocaine in adulthood, but it does so without altering the response of the mesolimbic dopamine system.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalBehavioural Brain Research
Volume167
Issue number2
DOIs
StatePublished - Feb 28 2006

Keywords

  • Dopamine
  • In vivo microdialysis
  • Nucleus accumbens
  • Place conditioning
  • Psychostimulants
  • SHR rat

ASJC Scopus subject areas

  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder'. Together they form a unique fingerprint.

  • Cite this