Differential olanzapine plasma concentrations by sex in a fixed-dose study

Deanna L. Kelly, Robert R. Conley, Carol A. Tamminga

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

This study examined plasma concentrations of olanzapine by sex (20 males and seven females) in an 8-week fixed-dose study. Dosing was 12.5 mg/day for the first week, then 25 mg/day. Trough plasma concentrations were drawn at weeks 1, 3, 5 and 8. Women volunteers were found to have significantly higher plasma concentrations than men. This difference was first evident at study week 5. Women have higher plasma concentrations of olanzapine, possibly due to differences in metabolism of the CYP450 isoenzyme system. (C) 1999 Elsevier Science B.V. All rights reserved.

Original languageEnglish (US)
Pages (from-to)101-104
Number of pages4
JournalSchizophrenia Research
Volume40
Issue number2
DOIs
StatePublished - Nov 30 1999

Keywords

  • Atypical antipsychotic
  • Olanzapine
  • Plasma concentration
  • Sex

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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