Differential olanzapine plasma concentrations by sex in a fixed-dose study

Deanna L. Kelly; Robert R. Conley; Carol A. Tamminga

doi:10.1016/S0920-9964(99)00053-5

Differential olanzapine plasma concentrations by sex in a fixed-dose study

Deanna L. Kelly, Robert R. Conley, Carol A. Tamminga

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

This study examined plasma concentrations of olanzapine by sex (20 males and seven females) in an 8-week fixed-dose study. Dosing was 12.5 mg/day for the first week, then 25 mg/day. Trough plasma concentrations were drawn at weeks 1, 3, 5 and 8. Women volunteers were found to have significantly higher plasma concentrations than men. This difference was first evident at study week 5. Women have higher plasma concentrations of olanzapine, possibly due to differences in metabolism of the CYP450 isoenzyme system. (C) 1999 Elsevier Science B.V. All rights reserved.

Original language	English (US)
Pages (from-to)	101-104
Number of pages	4
Journal	Schizophrenia Research
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/S0920-9964(99)00053-5
State	Published - Nov 30 1999

Keywords

Atypical antipsychotic
Olanzapine
Plasma concentration
Sex

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/S0920-9964(99)00053-5

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title = "Differential olanzapine plasma concentrations by sex in a fixed-dose study",

abstract = "This study examined plasma concentrations of olanzapine by sex (20 males and seven females) in an 8-week fixed-dose study. Dosing was 12.5 mg/day for the first week, then 25 mg/day. Trough plasma concentrations were drawn at weeks 1, 3, 5 and 8. Women volunteers were found to have significantly higher plasma concentrations than men. This difference was first evident at study week 5. Women have higher plasma concentrations of olanzapine, possibly due to differences in metabolism of the CYP450 isoenzyme system. (C) 1999 Elsevier Science B.V. All rights reserved.",

keywords = "Atypical antipsychotic, Olanzapine, Plasma concentration, Sex",

author = "Kelly, {Deanna L.} and Conley, {Robert R.} and Tamminga, {Carol A.}",

note = "Funding Information: This research was supported in part by NIMH grants MH-47311 and MH-40279. Olanzapine tablets and blood levels were supplied by Eli Lilly Company.",

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AU - Kelly, Deanna L.

AU - Conley, Robert R.

AU - Tamminga, Carol A.

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N2 - This study examined plasma concentrations of olanzapine by sex (20 males and seven females) in an 8-week fixed-dose study. Dosing was 12.5 mg/day for the first week, then 25 mg/day. Trough plasma concentrations were drawn at weeks 1, 3, 5 and 8. Women volunteers were found to have significantly higher plasma concentrations than men. This difference was first evident at study week 5. Women have higher plasma concentrations of olanzapine, possibly due to differences in metabolism of the CYP450 isoenzyme system. (C) 1999 Elsevier Science B.V. All rights reserved.

AB - This study examined plasma concentrations of olanzapine by sex (20 males and seven females) in an 8-week fixed-dose study. Dosing was 12.5 mg/day for the first week, then 25 mg/day. Trough plasma concentrations were drawn at weeks 1, 3, 5 and 8. Women volunteers were found to have significantly higher plasma concentrations than men. This difference was first evident at study week 5. Women have higher plasma concentrations of olanzapine, possibly due to differences in metabolism of the CYP450 isoenzyme system. (C) 1999 Elsevier Science B.V. All rights reserved.

KW - Atypical antipsychotic

KW - Olanzapine

KW - Plasma concentration

KW - Sex

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Differential olanzapine plasma concentrations by sex in a fixed-dose study

Abstract

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