Differential regulation of embryonic and adult β cell replication

Uma Gunasekaran, Courtney W. Hudgens, Brian T. Wright, Matthew F. Maulis, Maureen Gannon

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Diabetes results from an inadequate functional β cell mass, either due to autoimmune destruction (Type 1 diabetes) or insulin resistance combined with β cell failure (Type 2 diabetes). Strategies to enhance β cell regeneration or increase cell proliferation could improve outcomes for patients with diabetes. Research conducted over the past several years has revealed that factors regulating embryonic β cell mass expansion differ from those regulating replication of βcells post-weaning. This article aims to compare and contrast factors known to control embryonic and postnatal β cell replication. In addition, we explore the possibility that connective tissue growth factor (CTGF) could increase adult β cell replication. We have already shown that CTGF is required for embryonic β cell proliferation and is sufficient to induce replication of embryonic β cells. Here we examine whether adult β cell replication and expansion of β cell mass can be enhanced by increased CTGF expression in mature β cells.

Original languageEnglish (US)
Pages (from-to)2431-2442
Number of pages12
JournalCell Cycle
Volume11
Issue number13
DOIs
StatePublished - Jul 1 2012

Keywords

  • Connective tissue growth factor
  • Diabetes
  • Embryogenesis
  • Pancreatic β cell
  • Replication

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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  • Cite this

    Gunasekaran, U., Hudgens, C. W., Wright, B. T., Maulis, M. F., & Gannon, M. (2012). Differential regulation of embryonic and adult β cell replication. Cell Cycle, 11(13), 2431-2442. https://doi.org/10.4161/cc.20545