Differential response of Period 1 expression within the suprachiasmatic nucleus

Wataru Nakamura, Shin Yamazaki, Nana N. Takasu, Kazuo Mishima, Gene D. Block

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The suprachiasmatic nuclei (SCNs) of the hypothalamus contain a circadian clock that exerts profound control over rhythmic physiology and behavior. The clock consists of multiple autonomous cellular pacemakers distributed throughout the rat SCN. In response to a shift in the light schedule, the SCN rapidly changes phase to achieve the appropriate phase relationship with the shifted light schedule. Through use of a transgenic rat in which rhythmicity in transcription of the Period 1 gene was measured with a luciferase reporter (Per1-luc), we have been successful in tracking the time c ourse of molecular rhythm phase readjustments in different regions of the SCN that occur in response to a shift in the light schedule. We find that different regions of the SCN phase adjust at different rates, leading to transient internal desynchrony in Per1-luc expression among SCN regions. This desynchrony among regions is most pronounced and prolonged when the light schedule is advanced compared with light schedule delays. A similar asymmetry in the speed of phase resetting is observed with locomotor behavior, suggesting that phase shifting kinetics within the SCN may underlay the differences observed in behavioral resetting to advances or delays in the light schedule.

Original languageEnglish (US)
Pages (from-to)5481-5487
Number of pages7
JournalJournal of Neuroscience
Volume25
Issue number23
DOIs
StatePublished - Jun 8 2005

Fingerprint

Suprachiasmatic Nucleus
Appointments and Schedules
Light
Transgenic Rats
Circadian Clocks
Periodicity
Luciferases
Hypothalamus
Genes

Keywords

  • Circadian
  • Desynchronization
  • Entrainment
  • Light
  • Suprachiasmatic
  • Synchrony

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Differential response of Period 1 expression within the suprachiasmatic nucleus. / Nakamura, Wataru; Yamazaki, Shin; Takasu, Nana N.; Mishima, Kazuo; Block, Gene D.

In: Journal of Neuroscience, Vol. 25, No. 23, 08.06.2005, p. 5481-5487.

Research output: Contribution to journalArticle

Nakamura, Wataru ; Yamazaki, Shin ; Takasu, Nana N. ; Mishima, Kazuo ; Block, Gene D. / Differential response of Period 1 expression within the suprachiasmatic nucleus. In: Journal of Neuroscience. 2005 ; Vol. 25, No. 23. pp. 5481-5487.
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