Differentiation of renal neoplasms from high-density cysts: Use of attenuation changes between the corticomedullary and nephrographic phases of computed tomography

Ronald J. Zagoria, Tyler Gasser, John R. Leyendecker, Robert E. Bechtold, Raymond B. Dyer

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

PURPOSE: The current study evaluated attenuation changes for proven renal neoplasms between the corticomedullary and the nephrographic phases of a contrast-enhanced computed tomographic (CT) scan as a possible means for differentiating these tumors from the cysts of the kidney when high-density renal masses are detected on a CT scan that does not include a noncontrast baseline. METHODS: We retrospectively reviewed the CT scans performed on 20 patients with 21 biopsy-proven renal neoplasms, which had been done using standard contrast-enhanced computed tomography only. Attenuation values for the 21 renal neoplasms and for 23 simple cysts, used as an internal control, were measured and recorded from the 2 phases of enhancement. The difference in attenuation between the 2 phases of enhancement for each mass was calculated. Data for the neoplasms and cysts were compared with published data for enhancement changes for proven high-density renal cysts. RESULTS: The mean absolute value change in attenuation between the corticomedullary and the nephrographic phases for renal neoplasms was 22 Hounsfield units (HU) (range, 1.0-48 HU) and 1 HU (range, 0.1-3.3 HU) for simple cysts. Only one renal neoplasm (5%) changed to less than 10 HU. CONCLUSIONS: Almost all renal neoplasms studied had an attenuation change of more than 10 HU, either increased or decreased, between 2phases of a contrast-enhanced CT scan separated by 50 seconds. The results suggest that if the attenuation of a renal tumor changes by more than 10 HU between phases of a contrast-enhanced computed tomography, then the diagnosis of renal neoplasm is very likely. High-attenuation renal masses which change less than 10 HU between the corticomedullary and tubular phases are most likely high-density cysts, but neoplasm is possible.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalJournal of Computer Assisted Tomography
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2007

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Kidney Neoplasms
Cysts
Tomography
Kidney
Neoplasms
Biopsy

Keywords

  • Contrast enhancement
  • CT
  • High-density cyst
  • Renal cell carcinoma
  • Renal neoplasm

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Differentiation of renal neoplasms from high-density cysts : Use of attenuation changes between the corticomedullary and nephrographic phases of computed tomography. / Zagoria, Ronald J.; Gasser, Tyler; Leyendecker, John R.; Bechtold, Robert E.; Dyer, Raymond B.

In: Journal of Computer Assisted Tomography, Vol. 31, No. 1, 01.01.2007, p. 37-41.

Research output: Contribution to journalReview article

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title = "Differentiation of renal neoplasms from high-density cysts: Use of attenuation changes between the corticomedullary and nephrographic phases of computed tomography",
abstract = "PURPOSE: The current study evaluated attenuation changes for proven renal neoplasms between the corticomedullary and the nephrographic phases of a contrast-enhanced computed tomographic (CT) scan as a possible means for differentiating these tumors from the cysts of the kidney when high-density renal masses are detected on a CT scan that does not include a noncontrast baseline. METHODS: We retrospectively reviewed the CT scans performed on 20 patients with 21 biopsy-proven renal neoplasms, which had been done using standard contrast-enhanced computed tomography only. Attenuation values for the 21 renal neoplasms and for 23 simple cysts, used as an internal control, were measured and recorded from the 2 phases of enhancement. The difference in attenuation between the 2 phases of enhancement for each mass was calculated. Data for the neoplasms and cysts were compared with published data for enhancement changes for proven high-density renal cysts. RESULTS: The mean absolute value change in attenuation between the corticomedullary and the nephrographic phases for renal neoplasms was 22 Hounsfield units (HU) (range, 1.0-48 HU) and 1 HU (range, 0.1-3.3 HU) for simple cysts. Only one renal neoplasm (5{\%}) changed to less than 10 HU. CONCLUSIONS: Almost all renal neoplasms studied had an attenuation change of more than 10 HU, either increased or decreased, between 2phases of a contrast-enhanced CT scan separated by 50 seconds. The results suggest that if the attenuation of a renal tumor changes by more than 10 HU between phases of a contrast-enhanced computed tomography, then the diagnosis of renal neoplasm is very likely. High-attenuation renal masses which change less than 10 HU between the corticomedullary and tubular phases are most likely high-density cysts, but neoplasm is possible.",
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T1 - Differentiation of renal neoplasms from high-density cysts

T2 - Use of attenuation changes between the corticomedullary and nephrographic phases of computed tomography

AU - Zagoria, Ronald J.

AU - Gasser, Tyler

AU - Leyendecker, John R.

AU - Bechtold, Robert E.

AU - Dyer, Raymond B.

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N2 - PURPOSE: The current study evaluated attenuation changes for proven renal neoplasms between the corticomedullary and the nephrographic phases of a contrast-enhanced computed tomographic (CT) scan as a possible means for differentiating these tumors from the cysts of the kidney when high-density renal masses are detected on a CT scan that does not include a noncontrast baseline. METHODS: We retrospectively reviewed the CT scans performed on 20 patients with 21 biopsy-proven renal neoplasms, which had been done using standard contrast-enhanced computed tomography only. Attenuation values for the 21 renal neoplasms and for 23 simple cysts, used as an internal control, were measured and recorded from the 2 phases of enhancement. The difference in attenuation between the 2 phases of enhancement for each mass was calculated. Data for the neoplasms and cysts were compared with published data for enhancement changes for proven high-density renal cysts. RESULTS: The mean absolute value change in attenuation between the corticomedullary and the nephrographic phases for renal neoplasms was 22 Hounsfield units (HU) (range, 1.0-48 HU) and 1 HU (range, 0.1-3.3 HU) for simple cysts. Only one renal neoplasm (5%) changed to less than 10 HU. CONCLUSIONS: Almost all renal neoplasms studied had an attenuation change of more than 10 HU, either increased or decreased, between 2phases of a contrast-enhanced CT scan separated by 50 seconds. The results suggest that if the attenuation of a renal tumor changes by more than 10 HU between phases of a contrast-enhanced computed tomography, then the diagnosis of renal neoplasm is very likely. High-attenuation renal masses which change less than 10 HU between the corticomedullary and tubular phases are most likely high-density cysts, but neoplasm is possible.

AB - PURPOSE: The current study evaluated attenuation changes for proven renal neoplasms between the corticomedullary and the nephrographic phases of a contrast-enhanced computed tomographic (CT) scan as a possible means for differentiating these tumors from the cysts of the kidney when high-density renal masses are detected on a CT scan that does not include a noncontrast baseline. METHODS: We retrospectively reviewed the CT scans performed on 20 patients with 21 biopsy-proven renal neoplasms, which had been done using standard contrast-enhanced computed tomography only. Attenuation values for the 21 renal neoplasms and for 23 simple cysts, used as an internal control, were measured and recorded from the 2 phases of enhancement. The difference in attenuation between the 2 phases of enhancement for each mass was calculated. Data for the neoplasms and cysts were compared with published data for enhancement changes for proven high-density renal cysts. RESULTS: The mean absolute value change in attenuation between the corticomedullary and the nephrographic phases for renal neoplasms was 22 Hounsfield units (HU) (range, 1.0-48 HU) and 1 HU (range, 0.1-3.3 HU) for simple cysts. Only one renal neoplasm (5%) changed to less than 10 HU. CONCLUSIONS: Almost all renal neoplasms studied had an attenuation change of more than 10 HU, either increased or decreased, between 2phases of a contrast-enhanced CT scan separated by 50 seconds. The results suggest that if the attenuation of a renal tumor changes by more than 10 HU between phases of a contrast-enhanced computed tomography, then the diagnosis of renal neoplasm is very likely. High-attenuation renal masses which change less than 10 HU between the corticomedullary and tubular phases are most likely high-density cysts, but neoplasm is possible.

KW - Contrast enhancement

KW - CT

KW - High-density cyst

KW - Renal cell carcinoma

KW - Renal neoplasm

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