Differentiation of T-helper lymphocytes: Selective regulation by members of the STAT family of transcription factors

Ulrike Schindler, Timothy Hoey, Steven L. McKnight

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Interleukin-4 (IL-4) and interleukin-12 (IL-12) control the differentiation of T-helper cells. Here we summarize studies which investigate the mechanism by which these cytokines selectively reprogramme gene expression in T-lymphocytes. Cytokine stimulation leads to the phosphorylation of specific tyrosine residues within the intracellular domain of the corresponding cytokine receptor. These phosphotyrosines serve as docking sites for latent, cytoplasmic transcription factors known as signal transducers and activators of transcription (Stat) proteins. Receptor/Stat interaction is mediated by the src homology 2 (SH2) domain of the corresponding Stat protein. Although Stat binding to the intracellular domain of the cytokine receptor strongly depends on the phosphotyrosine residue, the recruitment of a specific Stat protein is dictated by amino acid residues C-terminal to the phosphotyrosine. Specific docking sites within individual cytokine receptors have been identified for almost all Stat proteins. The direct coupling between cytokine receptor and transcription factor helps to explain how different cytokines elicit distinct patterns of gene expression.

Original languageEnglish (US)
Pages (from-to)507-515
Number of pages9
JournalGenes to Cells
Volume1
Issue number6
StatePublished - 1996

Fingerprint

STAT Transcription Factors
Cytokine Receptors
Helper-Inducer T-Lymphocytes
Phosphotyrosine
Cytokines
Transducers
Transcription Factors
Gene Expression
src Homology Domains
Interleukin-12
Interleukin-4
Tyrosine
Phosphorylation
T-Lymphocytes
Amino Acids

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Cite this

Differentiation of T-helper lymphocytes : Selective regulation by members of the STAT family of transcription factors. / Schindler, Ulrike; Hoey, Timothy; McKnight, Steven L.

In: Genes to Cells, Vol. 1, No. 6, 1996, p. 507-515.

Research output: Contribution to journalArticle

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