Dimeric quaternary structure of human laforin

Rajeshwer S. Sankhala, Adem C. Koksal, Lan Ho, Felix Nitschke, Berge A. Minassian, Gino Cingolani

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: Laforin is an essential glycogen phosphatase often mutated in Lafora disease. Results: Human laforin adopts a dimeric quaternary structure. Conclusion: Dimerization generates a unique active site crevice essential to recognize and dephosphorylate glycogen. Significance: We derived a complete structural model of human laforin using hybrid structural methods.

Original languageEnglish (US)
Pages (from-to)4552-4559
Number of pages8
JournalJournal of Biological Chemistry
Volume290
Issue number8
DOIs
StatePublished - Feb 20 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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