Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema

Kristen E. Adams, John C. Rasmussen, Chinmay Darne, I. Chih Tan, Melissa B. Aldrich, Milton V. Marshall, Caroline E. Fife, Erik A. Maus, Latisha A. Smith, Renie Guilloid, Sunday Hoy, Eva M. Sevick-Muraca

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Lymphedema affects up to 50% of all breast cancer survivors. Management with pneumatic compression devices (PCDs) is controversial, owing to the lack of methods to directly assess benefit. This pilot study employed an investigational, near-infrared (NIR) fluorescence imaging technique to evaluate lymphatic response to PCD therapy in normal control and breast cancer-related lymphedema (BCRL) subjects. Lymphatic propulsion rate, apparent lymph velocity, and lymphatic vessel recruitment were measured before, during, and after advanced PCD therapy. Lymphatic function improved in all control subjects and all asymptomatic arms of BCRL subjects. Lymphatic function improved in 4 of 6 BCRL affected arms, improvement defined as proximal movement of dye after therapy. NIR fluorescence lymphatic imaging may be useful to directly evaluate lymphatic response to therapy. These results suggest that PCDs can stimulate lymphatic function and may be an effective method to manage BCRL, warranting future clinical trials.

Original languageEnglish (US)
Pages (from-to)114-125
Number of pages12
JournalBiomedical Optics Express
Volume1
Issue number1
DOIs
StatePublished - Aug 2 2010

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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    Adams, K. E., Rasmussen, J. C., Darne, C., Tan, I. C., Aldrich, M. B., Marshall, M. V., Fife, C. E., Maus, E. A., Smith, L. A., Guilloid, R., Hoy, S., & Sevick-Muraca, E. M. (2010). Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema. Biomedical Optics Express, 1(1), 114-125. https://doi.org/10.1364/BOE.1.000114