Discharge prescribing of enteral opioids in opioid naïve patients following non-surgical intensive care: A retrospective cohort study

Luis E. Tollinche, Kenneth P. Seier, Gloria Yang, Kay See Tan, Yekaterina D. Tayban, Stephen M. Pastores, Cindy B. Yeoh, Kunal Karamchandani

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To estimate the incidence of new prescription of enteral opioids on hospital discharge in opioid naïve, non-surgical, critically ill patients and evaluate the risk factors associated with such occurrence. Methods: Using hospital-wide and ICU databases, we retrospectively identified all patients (≥ 18 years old) who were admitted to the 20-bed adult ICU of Memorial Sloan Kettering Cancer Center (MSKCC) between July 1, 2015 and April 20, 2020. Patients' electronic medical records (EMR) were retrieved and patient demographics, peri-ICU admission data were captured and analyzed. Results: During the study period, a total of 3755 opioid naïve patients were admitted to the ICU and 848 patients met the inclusion criteria. Among these, 346 (40.8%) patients were discharged with a new opioid prescription. Age at ICU admission, preadmission use of benzodiazepine, and antidepressants, a diagnosis of sepsis, and use of mechanical ventilation, antidepressants or, opioid infusion for greater than 4 h during the ICU stay, hospital length of stay (LOS), and days between ICU discharge and hospital discharge were independently associated with increased odds of a new opioid prescription. Conclusions: A significant proportion of opioid naïve non-surgical ICU survivors receive a new opioid prescription on hospital discharge.

Original languageEnglish (US)
Pages (from-to)16-21
Number of pages6
JournalJournal of Critical Care
Volume68
DOIs
StatePublished - Apr 2022

Keywords

  • Addiction
  • Analgesics
  • Cohort studies
  • Critical Illness
  • Opioid
  • Patient discharge
  • Risk factors

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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