Disseminated histoplasmosis in patients with AIDS

S. D. Nightingale, J. M. Parks, S. M. Pounders, D. K. Burns, J. Reynolds, J. A. Hernandez

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Disseminated histoplasmosis was diagnosed in 36 (4%) of 980 patients with AIDS seen at Parkland Memorial Hospital in Dallas, Texas before September 30, 1989. Diagnostic sensitivity of blood culture plus examination of peripheral smear was 88%; sensitivity of bone marrow aspiration and blood culture was 80%. Median CD4 lymphocyte count at diagnosis was 33/cu mm. Median actuarial survival from the date histoplasmosis was diagnosed was 188 days. Thirteen (36%) of the 36 patients died before adequate antifungal therapy could be administered, while 13 survived long enough to receive 1,500 mg of amphotericin B; actuarial survival of the latter group from the date 1,500 mg of amphotericin B had been infused was 47% at 1 year. The substantial early mortality of AIDS-associated disseminated histoplasmosis and the modestly encouraging survival of those who were diagnosed in time to receive adequate therapy raise the issues of surveillance, prophylaxis, and empiric therapy for this infection in selected HIV-positive patients.

Original languageEnglish (US)
Pages (from-to)624-630
Number of pages7
JournalSouthern Medical Journal
Volume83
Issue number6
DOIs
StatePublished - 1990

Fingerprint

Histoplasmosis
Acquired Immunodeficiency Syndrome
Amphotericin B
Survival
CD4 Lymphocyte Count
Therapeutics
Bone Marrow
HIV
Mortality
Infection
Blood Culture

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nightingale, S. D., Parks, J. M., Pounders, S. M., Burns, D. K., Reynolds, J., & Hernandez, J. A. (1990). Disseminated histoplasmosis in patients with AIDS. Southern Medical Journal, 83(6), 624-630. https://doi.org/10.1097/00007611-199006000-00007

Disseminated histoplasmosis in patients with AIDS. / Nightingale, S. D.; Parks, J. M.; Pounders, S. M.; Burns, D. K.; Reynolds, J.; Hernandez, J. A.

In: Southern Medical Journal, Vol. 83, No. 6, 1990, p. 624-630.

Research output: Contribution to journalArticle

Nightingale, SD, Parks, JM, Pounders, SM, Burns, DK, Reynolds, J & Hernandez, JA 1990, 'Disseminated histoplasmosis in patients with AIDS', Southern Medical Journal, vol. 83, no. 6, pp. 624-630. https://doi.org/10.1097/00007611-199006000-00007
Nightingale SD, Parks JM, Pounders SM, Burns DK, Reynolds J, Hernandez JA. Disseminated histoplasmosis in patients with AIDS. Southern Medical Journal. 1990;83(6):624-630. https://doi.org/10.1097/00007611-199006000-00007
Nightingale, S. D. ; Parks, J. M. ; Pounders, S. M. ; Burns, D. K. ; Reynolds, J. ; Hernandez, J. A. / Disseminated histoplasmosis in patients with AIDS. In: Southern Medical Journal. 1990 ; Vol. 83, No. 6. pp. 624-630.
@article{4748ed4b83bb48e294d9075aea4f6e45,
title = "Disseminated histoplasmosis in patients with AIDS",
abstract = "Disseminated histoplasmosis was diagnosed in 36 (4{\%}) of 980 patients with AIDS seen at Parkland Memorial Hospital in Dallas, Texas before September 30, 1989. Diagnostic sensitivity of blood culture plus examination of peripheral smear was 88{\%}; sensitivity of bone marrow aspiration and blood culture was 80{\%}. Median CD4 lymphocyte count at diagnosis was 33/cu mm. Median actuarial survival from the date histoplasmosis was diagnosed was 188 days. Thirteen (36{\%}) of the 36 patients died before adequate antifungal therapy could be administered, while 13 survived long enough to receive 1,500 mg of amphotericin B; actuarial survival of the latter group from the date 1,500 mg of amphotericin B had been infused was 47{\%} at 1 year. The substantial early mortality of AIDS-associated disseminated histoplasmosis and the modestly encouraging survival of those who were diagnosed in time to receive adequate therapy raise the issues of surveillance, prophylaxis, and empiric therapy for this infection in selected HIV-positive patients.",
author = "Nightingale, {S. D.} and Parks, {J. M.} and Pounders, {S. M.} and Burns, {D. K.} and J. Reynolds and Hernandez, {J. A.}",
year = "1990",
doi = "10.1097/00007611-199006000-00007",
language = "English (US)",
volume = "83",
pages = "624--630",
journal = "Southern Medical Journal",
issn = "0038-4348",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Disseminated histoplasmosis in patients with AIDS

AU - Nightingale, S. D.

AU - Parks, J. M.

AU - Pounders, S. M.

AU - Burns, D. K.

AU - Reynolds, J.

AU - Hernandez, J. A.

PY - 1990

Y1 - 1990

N2 - Disseminated histoplasmosis was diagnosed in 36 (4%) of 980 patients with AIDS seen at Parkland Memorial Hospital in Dallas, Texas before September 30, 1989. Diagnostic sensitivity of blood culture plus examination of peripheral smear was 88%; sensitivity of bone marrow aspiration and blood culture was 80%. Median CD4 lymphocyte count at diagnosis was 33/cu mm. Median actuarial survival from the date histoplasmosis was diagnosed was 188 days. Thirteen (36%) of the 36 patients died before adequate antifungal therapy could be administered, while 13 survived long enough to receive 1,500 mg of amphotericin B; actuarial survival of the latter group from the date 1,500 mg of amphotericin B had been infused was 47% at 1 year. The substantial early mortality of AIDS-associated disseminated histoplasmosis and the modestly encouraging survival of those who were diagnosed in time to receive adequate therapy raise the issues of surveillance, prophylaxis, and empiric therapy for this infection in selected HIV-positive patients.

AB - Disseminated histoplasmosis was diagnosed in 36 (4%) of 980 patients with AIDS seen at Parkland Memorial Hospital in Dallas, Texas before September 30, 1989. Diagnostic sensitivity of blood culture plus examination of peripheral smear was 88%; sensitivity of bone marrow aspiration and blood culture was 80%. Median CD4 lymphocyte count at diagnosis was 33/cu mm. Median actuarial survival from the date histoplasmosis was diagnosed was 188 days. Thirteen (36%) of the 36 patients died before adequate antifungal therapy could be administered, while 13 survived long enough to receive 1,500 mg of amphotericin B; actuarial survival of the latter group from the date 1,500 mg of amphotericin B had been infused was 47% at 1 year. The substantial early mortality of AIDS-associated disseminated histoplasmosis and the modestly encouraging survival of those who were diagnosed in time to receive adequate therapy raise the issues of surveillance, prophylaxis, and empiric therapy for this infection in selected HIV-positive patients.

UR - http://www.scopus.com/inward/record.url?scp=0025328623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025328623&partnerID=8YFLogxK

U2 - 10.1097/00007611-199006000-00007

DO - 10.1097/00007611-199006000-00007

M3 - Article

C2 - 2356493

AN - SCOPUS:0025328623

VL - 83

SP - 624

EP - 630

JO - Southern Medical Journal

JF - Southern Medical Journal

SN - 0038-4348

IS - 6

ER -