Distal renal tubular acidosis and calcium nephrolithiasis

Orson W. Moe, Daniel G. Fuster, Xiao Song Xie

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Calcium stones are commonly encountered in patients with congenital distal renal tubular acidosis, a disease of renal acidification caused by mutations in either the vacuolar H+ATPase (B1 or a4 subunit), anion exchanger-1, or carbonic anhydrase II. Based on the existing database, we present two hypotheses. First, heterozygotes with mutations in Bl subunit of H+-ATPase are not normal but may harbor biochemical abnormalities such as renal acidification defects, hypercalciuria, and hypocitraturia which can predispose them to kidney stone formation Second, we propose at least two mechanisms by which mutant B1 subunit can impair H+-ATPase: defective pump assembly and defective pump activity.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
Pages81-97
Number of pages17
Volume1049
DOIs
StatePublished - 2008
Event2nd International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Apr 17 2008Apr 18 2008

Other

Other2nd International Urolithiasis Research Symposium
CountryUnited States
CityIndianapolis, IN
Period4/17/084/18/08

Fingerprint

acidosis
mutations
calcium
kidney stones
carbonic anhydrase
pumps
exchangers
harbors
abnormalities
assembly
rocks
anions
defects

Keywords

  • Anion exchanger
  • Carbonic anhydrase
  • Membrane transport
  • Proton ATPase

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Moe, O. W., Fuster, D. G., & Xie, X. S. (2008). Distal renal tubular acidosis and calcium nephrolithiasis. In AIP Conference Proceedings (Vol. 1049, pp. 81-97) https://doi.org/10.1063/1.2998065

Distal renal tubular acidosis and calcium nephrolithiasis. / Moe, Orson W.; Fuster, Daniel G.; Xie, Xiao Song.

AIP Conference Proceedings. Vol. 1049 2008. p. 81-97.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Moe, OW, Fuster, DG & Xie, XS 2008, Distal renal tubular acidosis and calcium nephrolithiasis. in AIP Conference Proceedings. vol. 1049, pp. 81-97, 2nd International Urolithiasis Research Symposium, Indianapolis, IN, United States, 4/17/08. https://doi.org/10.1063/1.2998065
Moe OW, Fuster DG, Xie XS. Distal renal tubular acidosis and calcium nephrolithiasis. In AIP Conference Proceedings. Vol. 1049. 2008. p. 81-97 https://doi.org/10.1063/1.2998065
Moe, Orson W. ; Fuster, Daniel G. ; Xie, Xiao Song. / Distal renal tubular acidosis and calcium nephrolithiasis. AIP Conference Proceedings. Vol. 1049 2008. pp. 81-97
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