Distinct and sequential tissue-specific activitites of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development

Akio Kobayashi, Kin Ming Kwan, Thomas J. Carroll, Andrew P. McMahon, Cathy L. Mendelsohn, Richard R. Behringer

Research output: Contribution to journalArticle

232 Citations (Scopus)

Abstract

Kidney organogenesis requires the morphogenesis of epithelial tubules. Inductive interactions between the branching ureteric buds and the metanephric mesenchyme lead to mesenchyme-to-epithelium transitions and tubular morphogenesis to form nephrons, the functional units of the kidney. The LIM-class homeobox gene Lim1 is expressed in the intermediate mesoderm, nephric duct, mesonephric tubules, ureteric bud, pretubular aggregates and their derivatives. Lim1-null mice lack kidneys because of a failure of nephric duct formation, precluding studies of the role of Lim1 at later stages of kidney development. Here, we show that Lim1 functions in distinct tissue compartments of the developing metanephros for both proper development of the ureteric buds and the patterning of renal vesicles for nephron formation. These observations suggest that Lim1 has essential roles in multiple steps of epithelial tubular morphogenesis during kidney organogenesis. We also demonstrate that the nephric duct is essential for the elongation and maintenance of the adjacent Müllerian duct, the anlage of the female reproductive tract.

Original languageEnglish (US)
Pages (from-to)2809-2823
Number of pages15
JournalDevelopment
Volume132
Issue number12
DOIs
StatePublished - Jun 2005

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Homeobox Genes
Morphogenesis
Kidney
Mesoderm
Organogenesis
Nephrons
Wolffian Ducts
Epithelium
Maintenance

Keywords

  • Lhx1
  • Lim1
  • Mesonephros
  • Metanephros
  • Müllerian duct

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Distinct and sequential tissue-specific activitites of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. / Kobayashi, Akio; Kwan, Kin Ming; Carroll, Thomas J.; McMahon, Andrew P.; Mendelsohn, Cathy L.; Behringer, Richard R.

In: Development, Vol. 132, No. 12, 06.2005, p. 2809-2823.

Research output: Contribution to journalArticle

Kobayashi, Akio ; Kwan, Kin Ming ; Carroll, Thomas J. ; McMahon, Andrew P. ; Mendelsohn, Cathy L. ; Behringer, Richard R. / Distinct and sequential tissue-specific activitites of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. In: Development. 2005 ; Vol. 132, No. 12. pp. 2809-2823.
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