Distribution of cardiac output during induced isometric exercise in dogs

S. C. Crayton, R. Aung-Din, David E Fixler, Jere H Mitchell

Research output: Contribution to journalArticle

Abstract

Studies were designed to characterize the distribution of cardiac output during induced isometric exercise in anesthetized dogs. The response to isometric exercise involved significant increases in heart rate (+12 ± 3%(SE)), mean arterial pressure (+13 ± 2%), cardiac output (+26 ± 8%), and respiratory minute volume (+75 ± 26%); total peripheral resistance did not change significantly. Significant changes in blood flow were observed during isometric exercise in kidneys (-18 ± 6%) and contracting limb muscles (+453 ± 154%). Flow to liver (hepatic artery), spleen, brain, and myocardium remained near control values. Section of spinal dorsal roots L6-L7 abolished the responses to isometric exercise except for the increase in flow to exercising limb muscles. Alpha-adrenergic receptor blockade abolished the decrease in renal blood flow during isometric exercise; however, the increase in flow to exercising limb muscles was not affected by either alpha- or beta-adrenergic blockade.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume5
Issue number2
StatePublished - 1979

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Cardiac Output
Dogs
Exercise
Extremities
Spinal Nerve Roots
Muscles
Receptors, Adrenergic, alpha
Renal Circulation
Hepatic Artery
Vascular Resistance
Adrenergic Agents
Myocardium
Arterial Pressure
Spleen
Heart Rate
Kidney
Liver
Brain

ASJC Scopus subject areas

  • Physiology

Cite this

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abstract = "Studies were designed to characterize the distribution of cardiac output during induced isometric exercise in anesthetized dogs. The response to isometric exercise involved significant increases in heart rate (+12 ± 3{\%}(SE)), mean arterial pressure (+13 ± 2{\%}), cardiac output (+26 ± 8{\%}), and respiratory minute volume (+75 ± 26{\%}); total peripheral resistance did not change significantly. Significant changes in blood flow were observed during isometric exercise in kidneys (-18 ± 6{\%}) and contracting limb muscles (+453 ± 154{\%}). Flow to liver (hepatic artery), spleen, brain, and myocardium remained near control values. Section of spinal dorsal roots L6-L7 abolished the responses to isometric exercise except for the increase in flow to exercising limb muscles. Alpha-adrenergic receptor blockade abolished the decrease in renal blood flow during isometric exercise; however, the increase in flow to exercising limb muscles was not affected by either alpha- or beta-adrenergic blockade.",
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