DNA Repair

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This article discusses the multitude of mechanisms by which living cells repair spontaneous environmentally induced DNA damage. These include the removal of base damage from the genome by enzyme-catalyzed excision, the direct reversal of base damage by single-step enzyme-catalyzed reactions, and the repair of strand breaks in DNA. The relationships between defective DNA repair and human disease and the generation of mouse models of such diseases are also discussed.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages380-385
Number of pages6
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
StatePublished - Feb 27 2013

Keywords

  • Base excision repair
  • Cellular responses to DNA damage
  • DNA repair
  • DNA strand breaks
  • Enzymatic photoreactivation
  • Hereditary nonpolyposis colon cancer
  • Mismatch repair
  • Mouse models of DNA repair
  • Nucleotide excision repair
  • O-alkylguanine
  • Reversal of damage
  • Xeroderma pigmentosum

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Friedberg, E. C. (2013). DNA Repair. In Brenner's Encyclopedia of Genetics: Second Edition (pp. 380-385). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374984-0.00430-7