DNA repair and transcription

Prakash K. Bhatia, Zhigang Wang, Errol C. Friedberg

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The transcription factor TFIIH continues to be a subject of interest. In addition to its function as a repair and transcription factor, TFIIH includes a cyclin-dependent kinase and a cyclin, which raises the possibility that nucleotide excision repair (NER), RNA polymerase II transcription and cell cycle control are connected. Progress in mechanistic studies of NER include the identification of dual incision activities operating on either side of base damage and the isolation of a repairosome supercomplex in yeast. Additionally, NER has been demonstrated in reconstituted human and yeast systems, both of which include, TFIIH.

Original languageEnglish (US)
Pages (from-to)146-150
Number of pages5
JournalCurrent Opinion in Genetics and Development
Volume6
Issue number2
DOIs
StatePublished - Apr 1996

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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