Does exercise improve self-reported sleep quality in non-remitted major depressive disorder?

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background Sleep disturbances are persistent residual symptoms following remission of major depressive disorder (MDD) and are associated with an increased risk of MDD recurrence. The purpose of the current study was to examine the effect of exercise augmentation on self-reported sleep quality in participants with non-remitted MDD. Method Participants were randomized to receive selective serotonin reuptake inhibitor (SSRI) augmentation with one of two doses of exercise: 16 kilocalories per kilogram of body weight per week (KKW) or 4 KKW for 12 weeks. Depressive symptoms were assessed using the clinician-rated Inventory of Depressive Symptomatology (IDS-C). The four sleep-related items on the IDS-C (Sleep Onset Insomnia, Mid-Nocturnal Insomnia, Early Morning Insomnia, and Hypersomnia) were used to assess self-reported sleep quality. Results Significant decreases in total insomnia (p < 0.0001) were observed, along with decreases in sleep onset, mid-nocturnal and early-morning insomnia (p's <0.002). Hypersomnia did not change significantly (p = 0.38). Changes in total, mid-nocturnal and early-morning insomnia were independent of changes in depressive symptoms. Higher baseline hypersomnia predicted a greater decrease in depression severity following exercise treatment (p = 0.0057). No significant moderating effect of any baseline sleep on change in depression severity was observed. There were no significant differences between exercise treatment groups on total insomnia or any individual sleep item. Conclusions Exercise augmentation resulted in improvements in self-reported sleep quality in patients with non-remitted MDD. Given the prevalence of insomnia as a residual symptom following MDD treatment and the associated risk of MDD recurrence, exercise augmentation may have an important role in the treatment of MDD.

Original languageEnglish (US)
Pages (from-to)699-709
Number of pages11
JournalPsychological Medicine
Volume43
Issue number4
DOIs
StatePublished - Apr 2013

Fingerprint

Major Depressive Disorder
Sleep Initiation and Maintenance Disorders
Sleep
Exercise
Disorders of Excessive Somnolence
Depression
Recurrence
Serotonin Uptake Inhibitors
Therapeutics
Body Weight
Equipment and Supplies

Keywords

  • depression
  • exercise
  • insomnia
  • Key words Augmentation
  • physical activity
  • sleep

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Applied Psychology

Cite this

Does exercise improve self-reported sleep quality in non-remitted major depressive disorder? / Rethorst, C. D.; Sunderajan, P.; Greer, T. L.; Grannemann, B. D.; Nakonezny, P. A.; Carmody, T. J.; Trivedi, M. H.

In: Psychological Medicine, Vol. 43, No. 4, 04.2013, p. 699-709.

Research output: Contribution to journalArticle

@article{d4340ec79da7417a9bee7fd47b21d4a8,
title = "Does exercise improve self-reported sleep quality in non-remitted major depressive disorder?",
abstract = "Background Sleep disturbances are persistent residual symptoms following remission of major depressive disorder (MDD) and are associated with an increased risk of MDD recurrence. The purpose of the current study was to examine the effect of exercise augmentation on self-reported sleep quality in participants with non-remitted MDD. Method Participants were randomized to receive selective serotonin reuptake inhibitor (SSRI) augmentation with one of two doses of exercise: 16 kilocalories per kilogram of body weight per week (KKW) or 4 KKW for 12 weeks. Depressive symptoms were assessed using the clinician-rated Inventory of Depressive Symptomatology (IDS-C). The four sleep-related items on the IDS-C (Sleep Onset Insomnia, Mid-Nocturnal Insomnia, Early Morning Insomnia, and Hypersomnia) were used to assess self-reported sleep quality. Results Significant decreases in total insomnia (p{\^A} <{\^A} 0.0001) were observed, along with decreases in sleep onset, mid-nocturnal and early-morning insomnia (p's <0.002). Hypersomnia did not change significantly (p{\^A} ={\^A} 0.38). Changes in total, mid-nocturnal and early-morning insomnia were independent of changes in depressive symptoms. Higher baseline hypersomnia predicted a greater decrease in depression severity following exercise treatment (p{\^A} ={\^A} 0.0057). No significant moderating effect of any baseline sleep on change in depression severity was observed. There were no significant differences between exercise treatment groups on total insomnia or any individual sleep item. Conclusions Exercise augmentation resulted in improvements in self-reported sleep quality in patients with non-remitted MDD. Given the prevalence of insomnia as a residual symptom following MDD treatment and the associated risk of MDD recurrence, exercise augmentation may have an important role in the treatment of MDD.",
keywords = "depression, exercise, insomnia, Key words Augmentation, physical activity, sleep",
author = "Rethorst, {C. D.} and P. Sunderajan and Greer, {T. L.} and Grannemann, {B. D.} and Nakonezny, {P. A.} and Carmody, {T. J.} and Trivedi, {M. H.}",
year = "2013",
month = "4",
doi = "10.1017/S0033291712001675",
language = "English (US)",
volume = "43",
pages = "699--709",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",
number = "4",

}

TY - JOUR

T1 - Does exercise improve self-reported sleep quality in non-remitted major depressive disorder?

AU - Rethorst, C. D.

AU - Sunderajan, P.

AU - Greer, T. L.

AU - Grannemann, B. D.

AU - Nakonezny, P. A.

AU - Carmody, T. J.

AU - Trivedi, M. H.

PY - 2013/4

Y1 - 2013/4

N2 - Background Sleep disturbances are persistent residual symptoms following remission of major depressive disorder (MDD) and are associated with an increased risk of MDD recurrence. The purpose of the current study was to examine the effect of exercise augmentation on self-reported sleep quality in participants with non-remitted MDD. Method Participants were randomized to receive selective serotonin reuptake inhibitor (SSRI) augmentation with one of two doses of exercise: 16 kilocalories per kilogram of body weight per week (KKW) or 4 KKW for 12 weeks. Depressive symptoms were assessed using the clinician-rated Inventory of Depressive Symptomatology (IDS-C). The four sleep-related items on the IDS-C (Sleep Onset Insomnia, Mid-Nocturnal Insomnia, Early Morning Insomnia, and Hypersomnia) were used to assess self-reported sleep quality. Results Significant decreases in total insomnia (p < 0.0001) were observed, along with decreases in sleep onset, mid-nocturnal and early-morning insomnia (p's <0.002). Hypersomnia did not change significantly (p = 0.38). Changes in total, mid-nocturnal and early-morning insomnia were independent of changes in depressive symptoms. Higher baseline hypersomnia predicted a greater decrease in depression severity following exercise treatment (p = 0.0057). No significant moderating effect of any baseline sleep on change in depression severity was observed. There were no significant differences between exercise treatment groups on total insomnia or any individual sleep item. Conclusions Exercise augmentation resulted in improvements in self-reported sleep quality in patients with non-remitted MDD. Given the prevalence of insomnia as a residual symptom following MDD treatment and the associated risk of MDD recurrence, exercise augmentation may have an important role in the treatment of MDD.

AB - Background Sleep disturbances are persistent residual symptoms following remission of major depressive disorder (MDD) and are associated with an increased risk of MDD recurrence. The purpose of the current study was to examine the effect of exercise augmentation on self-reported sleep quality in participants with non-remitted MDD. Method Participants were randomized to receive selective serotonin reuptake inhibitor (SSRI) augmentation with one of two doses of exercise: 16 kilocalories per kilogram of body weight per week (KKW) or 4 KKW for 12 weeks. Depressive symptoms were assessed using the clinician-rated Inventory of Depressive Symptomatology (IDS-C). The four sleep-related items on the IDS-C (Sleep Onset Insomnia, Mid-Nocturnal Insomnia, Early Morning Insomnia, and Hypersomnia) were used to assess self-reported sleep quality. Results Significant decreases in total insomnia (p < 0.0001) were observed, along with decreases in sleep onset, mid-nocturnal and early-morning insomnia (p's <0.002). Hypersomnia did not change significantly (p = 0.38). Changes in total, mid-nocturnal and early-morning insomnia were independent of changes in depressive symptoms. Higher baseline hypersomnia predicted a greater decrease in depression severity following exercise treatment (p = 0.0057). No significant moderating effect of any baseline sleep on change in depression severity was observed. There were no significant differences between exercise treatment groups on total insomnia or any individual sleep item. Conclusions Exercise augmentation resulted in improvements in self-reported sleep quality in patients with non-remitted MDD. Given the prevalence of insomnia as a residual symptom following MDD treatment and the associated risk of MDD recurrence, exercise augmentation may have an important role in the treatment of MDD.

KW - depression

KW - exercise

KW - insomnia

KW - Key words Augmentation

KW - physical activity

KW - sleep

UR - http://www.scopus.com/inward/record.url?scp=84874943004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874943004&partnerID=8YFLogxK

U2 - 10.1017/S0033291712001675

DO - 10.1017/S0033291712001675

M3 - Article

VL - 43

SP - 699

EP - 709

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 4

ER -