Does planar cell polarity matter during spermatogenesis?

Linxi Li, Haiqi Chen, Qingquan Lian, Ren Shan Ge, C. Yan Cheng

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Planar cell polarity (PCP) has been extensively investigated for decades in Drosophila and also hair cells in cochlea. Recent studies have shown that many of the PCP proteins are well conserved, from flies to rodents and humans. In rodents and humans, the Van Gogh (Vang)/Prickle (Pk) complex, the frizzled (Fz)/dishevelled (Dvl)/inversin (Ivs) (or Diego (Dgo) in Drosophila) complex, and the Celsr (or flamingo (Fmi) in Drosophila) protein are crucial to confer PCP, both during embryogenesis such as gastrulation and also in adult cells/tissues. While there are few reports in the literature that examine the role of PCP proteins in spermatogenesis, emerging evidence has illustrated the importance of PCP during the seminiferous epithelial cycle of spermatogenesis. In this chapter, we carefully evaluate recent published data in light of the significance of PCP in Drosophila and highlight some of the areas of research that deserve attention in future research.

Original languageEnglish (US)
Title of host publicationSpermatogenesis
Subtitle of host publicationBiology and Clinical Implications
PublisherCRC Press
Number of pages9
ISBN (Electronic)9780429949494
ISBN (Print)9781498764117
StatePublished - Jan 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Does planar cell polarity matter during spermatogenesis?'. Together they form a unique fingerprint.

Cite this