Does surfactant type cause a differential proinflammatory response in preterm infants with respiratory distress syndrome?

Vanessa V. Mercado, Ioana Cristea, Noorjahan Ali, Chauchau Pham, Elizabeth Buescher, Jean Yang, Joie Fisher, Hima Maramreddy, Johanna Calo, Sonya Strassberg, Lance A. Parton

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Introduction: The objective of this study was to compare the pulmonary inflammatory response of premature infants with respiratory distress following instillation of one of two commonly available surfactant preparations. Methods: This was a prospective, randomized investigation of preterm infants who were less than 30 weeks of gestational age, weighed less than 1 kg at birth, and who qualified to receive surfactant. Infants with multiple congenital anomalies or whose mothers were taking anti-inflammatory medications were ineligible. Tracheal aspirates (TAs) were collected on days 1, 3, 5, and 7 and airway cytokines from TAs were assayed for interleukin (IL)-8 and IL-6. Results: Infants were evenly matched by gestation (26±2 days and 26±1 days [mean±SD], Surfactant A and B, respectively) and birth weight (730±141 g and 732±167 g). TA cytokine levels were not different between or within groups. Ventilator requirements and clinical outcomes were similar between the two groups. Conclusion: The postnatal airway inflammatory response observed in preterm infants is not altered by the instillation of either surfactant preparation.

Original languageEnglish (US)
Pages (from-to)476-482
Number of pages7
JournalAdvances in Therapy
Volume27
Issue number7
DOIs
StatePublished - Jul 2010

Keywords

  • bronchopulmonary dysplasia
  • cytokine interleukin 6
  • cytokine interleukin 8
  • natural surfactants
  • respiratory distress syndrome
  • tracheal aspirate cytokine

ASJC Scopus subject areas

  • Pharmacology (medical)

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    Mercado, V. V., Cristea, I., Ali, N., Pham, C., Buescher, E., Yang, J., Fisher, J., Maramreddy, H., Calo, J., Strassberg, S., & Parton, L. A. (2010). Does surfactant type cause a differential proinflammatory response in preterm infants with respiratory distress syndrome? Advances in Therapy, 27(7), 476-482. https://doi.org/10.1007/s12325-010-0044-3